Functional Description
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Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.Functional Description
Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. |
| Gene Ontology |
GO:0005829--C:cytosol
GO:0000228--C:nuclear chromosome
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005634--C:nucleus
GO:0070187--C:telosome
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0008301--F:DNA binding, bending
GO:0051880--F:G-quadruplex DNA binding
GO:0031492--F:nucleosomal DNA binding
GO:0001132--F:RNA polymerase II transcription factor activity, TBP-class protein binding RNA
GO:0042162--F:telomeric DNA binding
GO:0001094--F:TFIID-class transcription factor binding
GO:0000982--F:transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001076--F:transcription factor activity, RNA polymerase II transcription factor binding
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0035390--P:establishment of chromatin silencing at telomere
GO:0071169--P:establishment of protein localization to chromatin
GO:0070200--P:establishment of protein localization to telomere
GO:0071919--P:G-quadruplex DNA formation
GO:0031936--P:negative regulation of chromatin silencing
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031848--P:protection from non-homologous end joining at telomere
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0000723--P:telomere maintenance
GO:0010833--P:telomere maintenance via telomere lengthening
GO:0006351--P:transcription, DNA-templated
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