dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005553
Uniprot Accession P11792; SCH9_YEAST; D3DLF4;
Genbank Protein ID NP_012075.1;
Genbank Nucleotide ID NM_001179336.1;
Protein Name Serine/threonine-protein kinase SCH9
Protein Synonyms/Alias
Gene Name SCH9
Gene Synonyms/Alias KOM1;YHR205W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity.
Phosphorylation Sites
 dbPAF PTMs: 28 (View all)
PositionPeptidesSourceReferences ( PMIDs )
159TKCLLSSTSSLSINQcurated22369663
160KCLLSSTSSLSINQRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19366988; 25315811
161CLLSSTSSLSINQREcurated22369663
163LSSTSSLSINQREAAPhosphoGRID 2.019779198
285LKKKPLYTHRSSSQLcurated19823750
288KPLYTHRSSSQLDQLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20702584; 19779198; 17287358;
289PLYTHRSSSQLDQLNdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17287358; 19060867; 19366988;
290LYTHRSSSQLDQLNSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated15665377; 16381945; 23193290; 17287358; 19060867; 19366988;
297SQLDQLNSCSSVTDPcurated25315811
300DQLNSCSSVTDPSKRcurated25315811
466GERNILVTTASKSSPPhosphoGRID 2.020489023
568KADLKDRTNTFCGTTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20489023; 19779198;
570DLKDRTNTFCGTTEYdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 20489023; 15470109;
574RTNTFCGTTEYLAPEPhosphoPep 2.019060867
575TNTFCGTTEYLAPELPhosphoPep 2.0;curated19060867; 20377248
577TFCGTTEYLAPELLLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 25521595
587PELLLDETGYTKMVDcurated26040406
589LLLDETGYTKMVDFWcurated26040406
590LLDETGYTKMVDFWScurated26040406
711EFTTASTSYMNKHQPPhosphoGRID 2.0;PhosphoPep 2.0;curated17560372; 19060867; 24961812
Sequence
(Fasta)		MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG PCASSNNGAL 60
FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN NGISSVNNNN SNTPTIITTS 120
QEETNAGNVH GDTGGNSLQN SEDDNFSSSS TTKCLLSSTS SLSINQREAA AAAYGPDTDI 180
PRGKLEVTII EARDLVTRSK DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ 240
NQHINNNNEN TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS 300
VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA AHDHMFLGQV 360
RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK QTKKRHYGPQ DFEVLRLLGK 420
GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK KNEIAHTIGE RNILVTTASK SSPFIVGLKF 480
SFQTPTDLYL VTDYMSGGEL FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK 540
PENILLDANG NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV 600
LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR NPKHRLGAID 660
DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN FDPEFTTAST SYMNKHQPMM 720
TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI 780
DDDGDEDIND GFNQEKNMNN SHSQMDFDGD QHMDDEFVSG RFEI 825
Keyword

KW-0067--ATP-binding
KW-0114--cAMP
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR000961--AGC-kinase_C
IPR000008--C2_dom
IPR011009--Kinase-like_dom
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00168--C2
PF00069--Pkinase
PF00433--Pkinase_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000329--C:fungal-type vacuole membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0001324--P:age-dependent response to oxidative stress involved in chronological cell aging
GO:0060963--P:positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter
GO:0045943--P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945--P:positive regulation of transcription from RNA polymerase III promoter
GO:0006468--P:protein phosphorylation
GO:0032880--P:regulation of protein localization
GO:0047484--P:regulation of response to osmotic stress
GO:0090153--P:regulation of sphingolipid biosynthetic process
GO:0043619--P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0001302--P:replicative cell aging