| Tag |
Content |
| dbPAF ID |
dbPAF-0005549 |
| Uniprot Accession |
P11746; MCM1_YEAST; D6VZL8;
|
| Genbank Protein ID |
NP_013757.1;
|
| Genbank Nucleotide ID |
NM_001182540.1;
|
| Protein Name |
Pheromone receptor transcription factor |
| Protein Synonyms/Alias |
GRM/PRTF protein; |
| Gene Name |
MCM1 |
| Gene Synonyms/Alias |
FUN80;YMR043W;YM9532.08; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Transcription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine.Functional Description
Transcription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSDIEEGTPT NNGQQKERRK IEIKFIENKT RRHVTFSKRK HGIMKKAFEL SVLTGTQVLL 60
LVVSETGLVY TFSTPKFEPI VTQQEGRNLI QACLNAPDDE EEDEEEDGDD DDDDDDDGND 120
MQRQQPQQQQ PQQQQQVLNA HANSLGHLNQ DQVPAGALKQ EVKSQLLGGA NPNQNSMIQQ 180
QQHHTQNSQP QQQQQQQPQQ QMSQQQMSQH PRPQQGIPHP QQSQPQQQQQ QQQQLQQQQQ 240
QQQQQPLTGI HQPHQQAFAN AASPYLNAEQ NAAYQQYFQE PQQGQY
287Fasta Sequence
>P11746|MCM1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGNDMQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQQQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQQQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0056--Arginine metabolism
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR002100--TF_MADSbox
|
| PROSITE |
PS00350--MADS_BOX_1
PS50066--MADS_BOX_2
|
| Pfam |
PF00319--SRF-TF
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003688--F:DNA replication origin binding
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0044377--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0001133--F:RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0006525--P:arginine metabolic process
GO:0006270--P:DNA replication initiation
GO:1900465--P:negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter
GO:0001198--P:negative regulation of mating-type specific transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1900466--P:positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:0001197--P:positive regulation of mating-type specific transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0090282--P:positive regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0031494--P:regulation of mating type switching
GO:0006366--P:transcription from RNA polymerase II promoter
|
