dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005533
Uniprot Accession P11633; NHP6B_YEAST; A2TBM2; D6VQ90; P89500; P89501;
Genbank Protein ID NP_009647.2;
Genbank Nucleotide ID NM_001180058.2;
Protein Name Non-histone chromosomal protein 6B
Protein Synonyms/Alias
Gene Name NHP6B
Gene Synonyms/Alias NHPB;YBR089C-A;YBR090BC;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
47ENRDIVRSENPDVTFPhosphoGRID 2.021126336
53RSENPDVTFGQVGRIcurated22369663
Sequence
(Fasta)		MAATKEAKQP KEPKKRTTRR KKDPNAPKRG LSAYMFFANE NRDIVRSENP DVTFGQVGRI 60
LGERWKALTA EEKQPYESKA QADKKRYESE KELYNATRA
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR009071--HMG_box_dom
PROSITE

PS50118--HMG_BOX_2
Pfam

PF00505--HMG_box
Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0008301--F:DNA binding, bending
GO:0031491--F:nucleosome binding
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0001195--P:maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0070898--P:RNA polymerase III transcriptional preinitiation complex assembly
GO:0006366--P:transcription from RNA polymerase II promoter