| Tag |
Content |
| dbPAF ID |
dbPAF-0005532 |
| Uniprot Accession |
P11632; NHP6A_YEAST; D6W459;
|
| Genbank Protein ID |
NP_015377.1;
|
| Genbank Nucleotide ID |
NM_001184149.1;
|
| Protein Name |
Non-histone chromosomal protein 6A |
| Protein Synonyms/Alias |
|
| Gene Name |
NHP6A |
| Gene Synonyms/Alias |
NHPA;YPR052C;YP9499.09C; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B.Functional Description
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MVTPREPKKR TTRKKKDPNA PKRALSAYMF FANENRDIVR SENPDITFGQ VGKKLGEKWK 60
ALTPEEKQPY EAKAQADKKR YESEKELYNA TLA
94Fasta Sequence
>P11632|NHP6A|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MVTPREPKKRTTRKKKDPNAPKRALSAYMFFANENRDIVRSENPDITFGQVGKKLGEKWKALTPEEKQPYEAKAQADKKRYESEKELYNATLA
|
| Keyword |
KW-0002--3D-structure
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR009071--HMG_box_dom
|
| PROSITE |
PS50118--HMG_BOX_2
|
| Pfam |
PF00505--HMG_box
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0008301--F:DNA binding, bending
GO:0031491--F:nucleosome binding
GO:0006338--P:chromatin remodeling
GO:0034724--P:DNA replication-independent nucleosome organization
GO:0001195--P:maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter
GO:0006298--P:mismatch repair
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0070898--P:RNA polymerase III transcriptional preinitiation complex assembly
|
