| Tag |
Content |
| dbPAF ID |
dbPAF-0005525 |
| Uniprot Accession |
P11584; ITBX_DROME; Q8MYX9; Q9W3L2;
|
| Genbank Protein ID |
NP_001284998.1; NP_001284999.1; NP_524793.2;
|
| Genbank Nucleotide ID |
NM_001298069.1; NM_001298070.1; NM_080054.3;
|
| Protein Name |
Integrin beta-PS |
| Protein Synonyms/Alias |
Position-specific antigen beta subunit;Protein myospheroid;Protein olfactory C; |
| Gene Name |
mys |
| Gene Synonyms/Alias |
l(1)mys;olfC;CG1560; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and post-embryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. Plays a role in timely border cell migration during oogenesis.Functional Description
Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for many embryonic (dorsal closure and somatic muscle attachments) and post-embryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development). Involved in the function and/or development of the olfactory system. Plays a role in timely border cell migration during oogenesis. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 831 | DTGENPIYKQATSTF | PHOSIDA;curated | 21081558; 22817900 |
|
Sequence
(Fasta) | MILERNRRCQ LALLMIAILA AIAGQTDAQK AAKLTAVSTC ASKEKCHTCI QTEGCAWCMQ 60
PDFKGQSRCY QNTSSLCPEE FAYSPITVEQ ILVNNKLTNQ YKAELAAGGG GSAMSGSSSS 120
SYSSSSSSSS FYSQSSSGSS SASGYEEYSA GEIVQIQPQS MRLALRVNEK HNIKISYSQA 180
EGYPVDLYYL MDLSKSMEDD KAKLSTLGDK LSETMKRITN NFHLGFGSFV DKVLMPYVST 240
IPKKLEHPCE NCKAPYGYQN HMPLNNNTES FSNEVKNATV SGNLDAPEGG FDAIMQAIAC 300
RSQIGWREQA RRLLVFSTDA GFHYAGDGKL GGVIAPNDGE CHLSPKGEYT HSTLQDYPSI 360
SQINQKVKDN AINIIFAVTA SQLSVYEKLV EHIQGSSAAK LDNDSSNVVE LVKEEYRKIS 420
SSVEMKDNAT GDVKITYFSS CLSNGPEVQT SKCDNLKEGQ QVSFTAQIQL LKCPEDPRDW 480
TQTIHISPVG INEVMQIQLT MLCSCPCENP GSIGYQVQAN SCSGHGTSMC GICNCDDSYF 540
GNKCECSATD LTSKFANDTS CRADSTSTTD CSGRGHCVCG ACECHKRPNP IEIISGKHCE 600
CDNFSCERNR NQLCSGPDHG TCECGRCKCK PGWTGSNCGC QESNDTCMPP GGGEICSGHG 660
TCECGVCKCT VNDQGRFSGR HCEKCPTCSG RCQELKDCVQ CQMYKTGELK NGDDCARNCT 720
QFVPVGVEKV EIDETKDEQM CKFFDEDDCK FMFKYSEQGE LHVYAQENKE CPAKVFMLGI 780
VMGVIAAIVL VGLAILLLWK LLTTIHDRRE FARFEKERMN AKWDTGENPI YKQATSTFKN 840
PMYAGK
847Fasta Sequence
>P11584|mys|Drosophila melanogaster(Fruit fly)
MILERNRRCQLALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTEGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYAGK
|
| Keyword |
KW-0085--Behavior
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0286--Flight
KW-0325--Glycoprotein
KW-0401--Integrin
KW-0472--Membrane
KW-0552--Olfaction
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0844--Vision
|
| Interpro |
IPR000742--EGF-like_dom
IPR013111--EGF_extracell
IPR015812--Integrin_bsu
IPR014836--Integrin_bsu_cyt_dom
IPR002369--Integrin_bsu_N
IPR012896--Integrin_bsu_tail
IPR016201--Plexin-like_fold
IPR002035--VWF_A
|
| PROSITE |
PS00022--EGF_1
PS01186--EGF_2
PS00243--INTEGRIN_BETA
|
| Pfam |
PF07974--EGF_2
PF08725--Integrin_b_cyt
PF07965--Integrin_B_tail
PF00362--Integrin_beta
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0009925--C:basal plasma membrane
GO:0031252--C:cell leading edge
GO:0043034--C:costamere
GO:0005925--C:focal adhesion
GO:0005887--C:integral component of plasma membrane
GO:0008305--C:integrin complex
GO:0016328--C:lateral plasma membrane
GO:0005927--C:muscle tendon junction
GO:0005886--C:plasma membrane
GO:0050839--F:cell adhesion molecule binding
GO:0046982--F:protein heterodimerization activity
GO:0004872--F:receptor activity
GO:0007015--P:actin filament organization
GO:0007475--P:apposition of dorsal and ventral imaginal disc-derived wing surfaces
GO:0007411--P:axon guidance
GO:0007298--P:border follicle cell migration
GO:0016339--P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016340--P:calcium-dependent cell-matrix adhesion
GO:0007155--P:cell adhesion
GO:0033627--P:cell adhesion mediated by integrin
GO:0016477--P:cell migration
GO:0007160--P:cell-matrix adhesion
GO:0031589--P:cell-substrate adhesion
GO:0007417--P:central nervous system development
GO:0021551--P:central nervous system morphogenesis
GO:0008340--P:determination of adult lifespan
GO:0007391--P:dorsal closure
GO:0035001--P:dorsal trunk growth, open tracheal system
GO:0007427--P:epithelial cell migration, open tracheal system
GO:0007629--P:flight behavior
GO:0007377--P:germ-band extension
GO:0030718--P:germ-line stem cell population maintenance
GO:0035099--P:hemocyte migration
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0048803--P:imaginal disc-derived male genitalia morphogenesis
GO:0007229--P:integrin-mediated signaling pathway
GO:0007508--P:larval heart development
GO:0035160--P:maintenance of epithelial integrity, open tracheal system
GO:0007494--P:midgut development
GO:0016203--P:muscle attachment
GO:0007517--P:muscle organ development
GO:0030336--P:negative regulation of cell migration
GO:0003344--P:pericardium morphogenesis
GO:0008360--P:regulation of cell shape
GO:0051492--P:regulation of stress fiber assembly
GO:0007431--P:salivary gland development
GO:0045214--P:sarcomere organization
GO:0007608--P:sensory perception of smell
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0007426--P:tracheal outgrowth, open tracheal system
GO:0007601--P:visual perception
|
