dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005513
Uniprot Accession P11491; PPB_YEAST; D6VTA4; E9P949; Q03374;
Genbank Protein ID NP_010769.3;
Genbank Nucleotide ID NM_001180789.3;
Protein Name Repressible alkaline phosphatase
Protein Synonyms/Alias Fructose-2,6-bisphosphate 6-phosphatase;
Gene Name PHO8
Gene Synonyms/Alias YDR481C;D8035.24;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Phosphatase with broad substrate specificity. A truncated (soluble) version of the protein is responsible for the production of (E,E)-farnesol from (E,E)-farnesyl diphosphate. Acts as a fructose-2,6-bisphosphate 6-phosphatase (PubMed:1848184).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
17QTRLVPGSDSSSRPKPhosphoPep 2.0;curated19060867; 22817900
19RLVPGSDSSSRPKKRPhosphoPep 2.019060867
20LVPGSDSSSRPKKRRcurated22369663; 22817900
21VPGSDSSSRPKKRRIPhosphoPep 2.019060867
118SRTRSSDSLVTDSAAPhosphoGRID 2.019779198
121RSSDSLVTDSAAGATdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 26040289;
123SDSLVTDSAAGATAFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 21177495; 19684113;
128TDSAAGATAFACALKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MMTHTLPSEQ TRLVPGSDSS SRPKKRRISK RSKIIVSTVV CIGLLLVLVQ LAFPSSFALR 60
SASHKKKNVI FFVTDGMGPA SLSMARSFNQ HVNDLPIDDI LTLDEHFIGS SRTRSSDSLV 120
TDSAAGATAF ACALKSYNGA IGVDPHHRPC GTVLEAAKLA GYLTGLVVTT RITDATPASF 180
SSHVDYRWQE DLIATHQLGE YPLGRVVDLL MGGGRSHFYP QGEKASPYGH HGARKDGRDL 240
IDEAQSNGWQ YVGDRKNFDS LLKSHGENVT LPFLGLFADN DIPFEIDRDE KEYPSLKEQV 300
KVALGALEKA SNEDKDSNGF FLMVEGSRID HAGHQNDPAS QVREVLAFDE AFQYVLEFAE 360
NSDTETVLVS TSDHETGGLV TSRQVTASYP QYVWYPQVLA NATHSGEFLK RKLVDFVHEH 420
KGASSKIENF IKHEILEKDL GIYDYTDSDL ETLIHLDDNA NAIQDKLNDM VSFRAQIGWT 480
THGHSAVDVN IYAYANKKAT WSYVLNNLQG NHENTEVGQF LENFLELNLN EVTDLIRDTK 540
HTSDFDATEI ASEVQHYDEY YHELTN 567
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0926--Vacuole
KW-0862--Zinc
Interpro

IPR017849--Alkaline_Pase-like_a/b/a
IPR001952--Alkaline_phosphatase
IPR018299--Alkaline_phosphatase_AS
IPR017850--Alkaline_phosphatase_core
PROSITE

PS00123--ALKALINE_PHOSPHATASE
Pfam

PF00245--Alk_phosphatase
Gene Ontology

GO:0000329--C:fungal-type vacuole membrane
GO:0016021--C:integral component of membrane
GO:0004035--F:alkaline phosphatase activity
GO:0047386--F:fructose-2,6-bisphosphate 6-phosphatase activity
GO:0046872--F:metal ion binding
GO:0046496--P:nicotinamide nucleotide metabolic process
GO:0006470--P:protein dephosphorylation