dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005500
Uniprot Accession P11433; CDC24_YEAST; D6VPH5;
Genbank Protein ID NP_009359.1;
Genbank Nucleotide ID NM_001178186.1;
Protein Name Cell division control protein 24
Protein Synonyms/Alias Calcium regulatory protein;
Gene Name CDC24
Gene Synonyms/Alias CLS4;YAL041W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.
Phosphorylation Sites
 dbPAF PTMs: 48 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9AIQTRFASGTSLSDLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19668330; 19366988; 24961812;
11QTRFASGTSLSDLKPPhosphoGRID 2.0;curated19668330; 19823750; 24961812
12TRFASGTSLSDLKPKPhosphoGRID 2.0;curated19668330; 19823750; 24961812; 25315811
14FASGTSLSDLKPKPSPhosphoGRID 2.019668330
100SNGANRDSSDLAPTLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 17330950; 19668330;
101NGANRDSSDLAPTLRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 16381945; 23193290; 17330950; 21177495; 20702584;
106DSSDLAPTLRSSSISPhosphoGRID 2.0;curated19668330; 26040289
526SEVVTKKSASSLILKPhosphoGRID 2.0;curated19668330; 22817900; 25315811
528VVTKKSASSLILKKKPhosphoGRID 2.0;curated19668330; 22369663; 22817900; 24961812; 25315811
529VTKKSASSLILKKKScurated22369663; 22817900
539LKKKSSTSASISASNPhosphoGRID 2.019668330
553NITDNNGSPHHSYHKPhosphoGRID 2.0;curated19668330; 24961812
557NNGSPHHSYHKRHSNPhosphoGRID 2.019668330
558NGSPHHSYHKRHSNSPhosphoGRID 2.019668330
563HSYHKRHSNSSSSNNPhosphoGRID 2.019668330
565YHKRHSNSSSSNNIHPhosphoGRID 2.019668330
566HKRHSNSSSSNNIHLPhosphoGRID 2.019668330
567KRHSNSSSSNNIHLSPhosphoGRID 2.019668330
568RHSNSSSSNNIHLSSPhosphoGRID 2.0;curated19668330; 24961812
589IHSSTNSSDNNSNNScurated24961812
Sequence
(Fasta)		MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI RKRLEVLPQL 60
KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS SDLAPTLRSS SISTATSLMS 120
MEGISYTNSN PSATPNMEDT LLTFSMGILP ITMDCDPVTQ LSQLFQQGAP LCILFNSVKP 180
QFKLPVIASD DLKVCKKSIY DFILGCKKHF AFNDEELFTI SDVFANSTSQ LVKVLEVVET 240
LMNSSPTIFP SKSKTQQIMN AENQHRHQPQ QSSKKHNEYV KIIKEFVATE RKYVHDLEIL 300
DKYRQQLLDS NLITSEELYM LFPNLGDAID FQRRFLISLE INALVEPSKQ RIGALFMHSK 360
HFFKLYEPWS IGQNAAIEFL SSTLHKMRVD ESQRFIINNK LELQSFLYKP VQRLCRYPLL 420
VKELLAESSD DNNTKELEAA LDISKNIARS INENQRRTEN HQVVKKLYGR VVNWKGYRIS 480
KFGELLYFDK VFISTTNSSS EPEREFEVYL FEKIIILFSE VVTKKSASSL ILKKKSSTSA 540
SISASNITDN NGSPHHSYHK RHSNSSSSNN IHLSSSSAAA IIHSSTNSSD NNSNNSSSSS 600
LFKLSANEPK LDLRGRIMIM NLNQIIPQNN RSLNITWESI KEQGNFLLKF KNEETRDNWS 660
SCLQQLIHDL KNEQFKARHH SSTSTTSSTA KSSSMMSPTT TMNTPNHHNS RQTHDSMASF 720
SSSHMKRVSD VLPKRRTTSS SFESEIKSIS ENFKNSIPES SILFRISYNN NSNNTSSSEI 780
FTLLVEKVWN FDDLIMAINS KISNTHNNNI SPITKIKYQD EDGDFVVLGS DEDWNVAKEM 840
LAENNEKFLN IRLY 855
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
Interpro

IPR010481--CDC24
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR000270--PB1_dom
IPR011993--PH/PTB_dom
IPR001849--PH_domain
PROSITE

PS00741--DH_1
PS50010--DH_2
PS51745--PB1
PS50003--PH_DOMAIN
Pfam

PF06395--CDC24
PF00564--PB1
PF00621--RhoGEF
Gene Ontology

GO:0005935--C:cellular bud neck
GO:0005934--C:cellular bud tip
GO:0005737--C:cytoplasm
GO:0000131--C:incipient cellular bud site
GO:0043332--C:mating projection tip
GO:0005634--C:nucleus
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0000282--P:cellular bud site selection
GO:0043547--P:positive regulation of GTPase activity
GO:0072697--P:protein localization to cell cortex
GO:0007096--P:regulation of exit from mitosis
GO:0035023--P:regulation of Rho protein signal transduction
GO:0031106--P:septin ring organization
GO:0007264--P:small GTPase mediated signal transduction