| Tag |
Content |
| dbPAF ID |
dbPAF-0005496 |
| Uniprot Accession |
P11412; G6PD_YEAST; D6W0V2; E9P908;
|
| Genbank Protein ID |
NP_014158.1;
|
| Genbank Nucleotide ID |
NM_001183079.1;
|
| Protein Name |
Glucose-6-phosphate 1-dehydrogenase |
| Protein Synonyms/Alias |
|
| Gene Name |
ZWF1 |
| Gene Synonyms/Alias |
MET19;YNL241C;N1110; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).Functional Description
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MSEGPVKFEK NTVISVFGAS GDLAKKKTFP ALFGLFREGY LDPSTKIFGY ARSKLSMEED 60
LKSRVLPHLK KPHGEADDSK VEQFFKMVSY ISGNYDTDEG FDELRTQIEK FEKSANVDVP 120
HRLFYLALPP SVFLTVAKQI KSRVYAENGI TRVIVEKPFG HDLASARELQ KNLGPLFKEE 180
ELYRIDHYLG KELVKNLLVL RFGNQFLNAS WNRDNIQSVQ ISFKERFGTE GRGGYFDSIG 240
IIRDVMQNHL LQIMTLLTME RPVSFDPESI RDEKVKVLKA VAPIDTDDVL LGQYGKSEDG 300
SKPAYVDDDT VDKDSKCVTF AAMTFNIENE RWEGVPIMMR AGKALNESKV EIRLQYKAVA 360
SGVFKDIPNN ELVIRVQPDA AVYLKFNAKT PGLSNATQVT DLNLTYASRY QDFWIPEAYE 420
VLIRDALLGD HSNFVRDDEL DISWGIFTPL LKHIERPDGP TPEIYPYGSR GPKGLKEYMQ 480
KHKYVMPEKH PYAWPVTKPE DTKDN
506Fasta Sequence
>P11412|ZWF1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN
|
| Keyword |
KW-0007--Acetylation
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0313--Glucose metabolism
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR001282--G6P_DH
IPR019796--G6P_DH_AS
IPR022675--G6P_DH_C
IPR022674--G6P_DH_NAD-bd
IPR016040--NAD(P)-bd_dom
|
| PROSITE |
PS00069--G6P_DEHYDROGENASE
|
| Pfam |
PF02781--G6PD_C
PF00479--G6PD_N
|
| Gene Ontology |
GO:0004345--F:glucose-6-phosphate dehydrogenase activity
GO:0050661--F:NADP binding
GO:0006006--P:glucose metabolic process
GO:0006740--P:NADPH regeneration
GO:0009051--P:pentose-phosphate shunt, oxidative branch
GO:0042542--P:response to hydrogen peroxide
|
