dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005488
Uniprot Accession P11353; HEM6_YEAST; D6VS32;
Genbank Protein ID NP_010329.1;
Genbank Nucleotide ID NM_001180352.1;
Protein Name Oxygen-dependent coproporphyrinogen-III oxidase
Protein Synonyms/Alias
Gene Name HEM13
Gene Synonyms/Alias YDR044W;YD5112.02;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
277NLIYDRGTQFGLRTPcurated22817900; 19547744
283GTQFGLRTPGSRVESPhosphoGRID 2.0;curated19779198; 22817900
286FGLRTPGSRVESILMcurated22817900; 19547744
Sequence
(Fasta)		MPAPQDPRNL PIRQQMEALI RRKQAEITQG LESIDTVKFH ADTWTRGNDG GGGTSMVIQD 60
GTTFEKGGVN VSVVYGQLSP AAVSAMKADH KNLRLPEDPK TGLPVTDGVK FFACGLSMVI 120
HPVNPHAPTT HLNYRYFETW NQDGTPQTWW FGGGADLTPS YLYEEDGQLF HQLHKDALDK 180
HDTALYPRFK KWCDEYFYIT HRKETRGIGG IFFDDYDERD PQEILKMVED CFDAFLPSYL 240
TIVKRRKDMP YTKEEQQWQA IRRGRYVEFN LIYDRGTQFG LRTPGSRVES ILMSLPEHAS 300
WLYNHHPAPG SREAKLLEVT TKPREWVK 329
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0350--Heme biosynthesis
KW-0560--Oxidoreductase
KW-0627--Porphyrin biosynthesis
KW-1185--Reference proteome
Interpro

IPR001260--Coprogen_oxidase_aer
IPR018375--Coprogen_oxidase_CS
PROSITE

PS01021--COPROGEN_OXIDASE
Pfam

PF01218--Coprogen_oxidas
Gene Ontology

GO:0005829--C:cytosol
GO:0004109--F:coproporphyrinogen oxidase activity
GO:0042803--F:protein homodimerization activity
GO:0006783--P:heme biosynthetic process
GO:0006782--P:protoporphyrinogen IX biosynthetic process