| Tag |
Content |
| dbPAF ID |
dbPAF-0005485 |
| Uniprot Accession |
P11346; KRAF1_DROME; A8JUV5; Q0KHW7; Q8I086; Q8I0D9; Q8ISE1; Q8ISE2; Q8ISE3; Q9NEH9; Q9W4Z3;
|
| Genbank Protein ID |
NP_001096867.3; NP_525047.1;
|
| Genbank Nucleotide ID |
NM_001103397.3; NM_080308.4;
|
| Protein Name |
Raf homolog serine/threonine-protein kinase phl |
| Protein Synonyms/Alias |
|
| Gene Name |
phl |
| Gene Synonyms/Alias |
ph;CG2845; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of ras1 in the sev signal transduction pathway.Functional Description
Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of ras1 in the sev signal transduction pathway. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MSSESSTEGD SDLYDPLAEE LHNVQLVKHV TRENIDALNA KFANLQEPPA MYLIEYQELT 60
SKLHELEAKE QELMERLNSQ DQQEDSSLVE RFKEQPHYQN QTQILQQQRQ LARVHHGNDL 120
TDSLGSQPGS QCGTLTRQPK ILLRAHLPNQ QRTSVEVISG VRLCDALMKA LKLRQLTPDM 180
CEVSTTHSGR HIIPWHTDIG TLHVEEIFVR LLDKFPIRTH IKHQIIRKTF FSLVFCEGCR 240
RLLFTGFYCS QCNFRFHQRC ANRVPMLCQP FPMDSYYQLL LAENPDNGVG FPGRGTAVRF 300
NMSSRSRSRR CSSSGSSSSS KPPSSSSGNH RQGRPPRISQ DDRSNSAPNV CINNIRSVTS 360
EVQRSLIMQA RPPLPHPCTD HSNSTQASPT STLKHNRPRA RSADESNKNL LLRDAKSSEE 420
NWNILAEEIL IGPRIGSGSF GTVYRAHWHG PVAVKTLNVK TPSPAQLQAF KNEVAMLKKT 480
RHCNILLFMG CVSKPSLAIV TQWCEGSSLY KHVHVSETKF KLNTLIDIGR QVAQGMDYLH 540
AKNIIHRDLK SNNIFLHEDL SVKIGDFGLA TAKTRWSGEK QANQPTGSIL WMAPEVIRMQ 600
ELNPYSFQSD VYAFGIVMYE LLAECLPYGH ISNKDQILFM VGRGLLRPDM SQVRSDAPQA 660
LKRLAEDCIK YTPKDRPLFR PLLNMLENML RTLPKIHRSA SEPNLTQSQL QNDEFLYLPS 720
PKTPVNFNNF QFFGSAGNI
Fasta Sequence
>P11346|phl|Drosophila melanogaster(Fruit fly)
MSSESSTEGDSDLYDPLAEELHNVQLVKHVTRENIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQTQILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGVRLCDALMKALKLRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFPIRTHIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPNLTQSQLQNDEFLYLPSPKTPVNFNNFQFFGSAGNI
|
| Keyword |
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR011009--Kinase-like_dom
IPR002219--PE/DAG-bd
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR003116--Raf-like_ras-bd
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR029071--Ubiquitin-rel_dom
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50898--RBD
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
|
| Pfam |
PF00130--C1_1
PF07714--Pkinase_Tyr
PF02196--RBD
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0005057--F:receptor signaling protein activity
GO:0007298--P:border follicle cell migration
GO:0009267--P:cellular response to starvation
GO:0008069--P:dorsal/ventral axis specification, ovarian follicular epithelium
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007369--P:gastrulation
GO:0042386--P:hemocyte differentiation
GO:0030097--P:hemopoiesis
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0008586--P:imaginal disc-derived wing vein morphogenesis
GO:0002168--P:instar larval development
GO:0035171--P:lamellocyte differentiation
GO:0007552--P:metamorphosis
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0016242--P:negative regulation of macroautophagy
GO:0008284--P:positive regulation of cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0046534--P:positive regulation of photoreceptor cell differentiation
GO:0046579--P:positive regulation of Ras protein signal transduction
GO:0007428--P:primary branching, open tracheal system
GO:0046777--P:protein autophosphorylation
GO:0051726--P:regulation of cell cycle
GO:0030641--P:regulation of cellular pH
GO:0040014--P:regulation of multicellular organism growth
GO:0007165--P:signal transduction
GO:0007283--P:spermatogenesis
GO:0007362--P:terminal region determination
GO:0008293--P:torso signaling pathway
GO:0035309--P:wing and notum subfield formation
GO:0007472--P:wing disc morphogenesis
|
