| Tag |
Content |
| dbPAF ID |
dbPAF-0005451 |
| Uniprot Accession |
P11154; PYC1_YEAST; D6VU79;
|
| Genbank Protein ID |
NP_011453.1;
|
| Genbank Nucleotide ID |
NM_001180927.1;
|
| Protein Name |
Pyruvate carboxylase 1 |
| Protein Synonyms/Alias |
Pyruvic carboxylase 1;PCB 1; |
| Gene Name |
PYC1 |
| Gene Synonyms/Alias |
PYV;YGL062W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.Functional Description
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSQRKFAGLR DNFNLLGEKN KILVANRGEI PIRIFRTAHE LSMQTVAIYS HEDRLSTHKQ 60
KADEAYVIGE VGQYTPVGAY LAIDEIISIA QKHQVDFIHP GYGFLSENSE FADKVVKAGI 120
TWIGPPAEVI DSVGDKVSAR NLAAKANVPT VPGTPGPIET VEEALDFVNE YGYPVIIKAA 180
FGGGGRGMRV VREGDDVADA FQRATSEART AFGNGTCFVE RFLDKPKHIE VQLLADNHGN 240
VVHLFERDCS VQRRHQKVVE VAPAKTLPRE VRDAILTDAV KLAKECGYRN AGTAEFLVDN 300
QNRHYFIEIN PRIQVEHTIT EEITGIDIVA AQIQIAAGAS LPQLGLFQDK ITTRGFAIQC 360
RITTEDPAKN FQPDTGRIEV YRSAGGNGVR LDGGNAYAGT IISPHYDSML VKCSCSGSTY 420
EIVRRKMIRA LIEFRIRGVK TNIPFLLTLL TNPVFIEGTY WTTFIDDTPQ LFQMVSSQNR 480
AQKLLHYLAD VAVNGSSIKG QIGLPKLKSN PSVPHLHDAQ GNVINVTKSA PPSGWRQVLL 540
EKGPAEFARQ VRQFNGTLLM DTTWRDAHQS LLATRVRTHD LATIAPTTAH ALAGRFALEC 600
WGGATFDVAM RFLHEDPWER LRKLRSLVPN IPFQMLLRGA NGVAYSSLPD NAIDHFVKQA 660
KDNGVDIFRV FDALNDLEQL KVGVDAVKKA GGVVEATVCF SGDMLQPGKK YNLDYYLEIA 720
EKIVQMGTHI LGIKDMAGTM KPAAAKLLIG SLRAKYPDLP IHVHTHDSAG TAVASMTACA 780
LAGADVVDVA INSMSGLTSQ PSINALLASL EGNIDTGINV EHVRELDAYW AEMRLLYSCF 840
EADLKGPDPE VYQHEIPGGQ LTNLLFQAQQ LGLGEQWAET KRAYREANYL LGDIVKVTPT 900
SKVVGDLAQF MVSNKLTSDD VRRLANSLDF PDSVMDFFEG LIGQPYGGFP EPFRSDVLRN 960
KRRKLTCRPG LELEPFDLEK IREDLQNRFG DVDECDVASY NMYPRVYEDF QKMRETYGDL 1020
SVLPTRSFLS PLETDEEIEV VIEQGKTLII KLQAVGDLNK KTGEREVYFD LNGEMRKIRV 1080
ADRSQKVETV TKSKADMHDP LHIGAPMAGV IVEVKVHKGS LIKKGQPVAV LSAMKMEMII 1140
SSPSDGQVKE VFVSDGENVD SSDLLVLLED QVPVETKA
1179Fasta Sequence
>P11154|PYC1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MSQRKFAGLRDNFNLLGEKNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLEDQVPVETKA
|
| Keyword |
KW-0067--ATP-binding
KW-0092--Biotin
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0312--Gluconeogenesis
KW-0436--Ligase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc
|
| Interpro |
IPR013785--Aldolase_TIM
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR005481--BC-like_N
IPR001882--Biotin_BS
IPR011764--Biotin_carboxylation_dom
IPR005482--Biotin_COase_C
IPR000089--Biotin_lipoyl
IPR003379--Carboxylase_cons_dom
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR009057--Homeodomain-like
IPR016185--PreATP-grasp_dom
IPR000891--PYR_CT
IPR005930--Pyruv_COase
IPR011054--Rudment_hybrid_motif
IPR011053--Single_hybrid_motif
|
| PROSITE |
PS50975--ATP_GRASP
PS50979--BC
PS00188--BIOTIN
PS50968--BIOTINYL_LIPOYL
PS00866--CPSASE_1
PS00867--CPSASE_2
PS50991--PYR_CT
|
| Pfam |
PF02785--Biotin_carb_C
PF00364--Biotin_lipoyl
PF00289--CPSase_L_chain
PF02786--CPSase_L_D2
PF00682--HMGL-like
PF02436--PYC_OADA
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0009374--F:biotin binding
GO:0004075--F:biotin carboxylase activity
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0004736--F:pyruvate carboxylase activity
GO:0006094--P:gluconeogenesis
GO:0006090--P:pyruvate metabolic process
|
