dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005424
Uniprot Accession P10961; HSF_YEAST; D6VU70; P11529;
Genbank Protein ID NP_011442.3;
Genbank Nucleotide ID NM_001180938.3;
Protein Name Heat shock factor protein
Protein Synonyms/Alias
Gene Name HSF1
Gene Synonyms/Alias YGL073W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
26PRIEPLPSLNDDDIEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
72LDPQSAASPVPSSSFdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
97THLVRRGTPLGIYQTPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19779198; 19060867; 25704821; 22369663; 22817900
111TNLYGHNSRENTNPNcurated25315811
115GHNSRENTNPNSTLLcurated26040289
243HKVQDVKSGSIQSSScurated22817900
439IGLNRDNTGTIDELKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
450DELKSNDSFINDDRNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19366988; 22369663;
458FINDDRNSFTNATTNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22369663;
460NDDRNSFTNATTNARdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22369663; 22817900; 19547744
471TNARNNMSPNNDDNSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 21177495; 19779198; 19060867;
478SPNNDDNSIDTASTNPhosphoGRID 2.0;UniProt;curated19779198; 26040406; 22369663; 22817900
481NDDNSIDTASTNTTNcurated22817900
528NSNNNAGSPIRPYKQUniProt;curated19779198; 22369663; 22817900
545LLKNRANSSTSSENPdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 21177495; 21081558;
546LKNRANSSTSSENPSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated17563356; 16381945; 23193290; 19060867; 22817900; 19823750;
548NRANSSTSSENPSLTcurated20377248
549RANSSTSSENPSLTPcurated19823750; 20377248
555SSENPSLTPFDIESNcurated24961812
561LTPFDIESNNDRKIScurated24961812
Sequence
(Fasta)		MNNAANTGTT NESNVSDAPR IEPLPSLNDD DIEKILQPND IFTTDRTDAS TTSSTAIEDI 60
INPSLDPQSA ASPVPSSSFF HDSRKPSTST HLVRRGTPLG IYQTNLYGHN SRENTNPNST 120
LLSSKLLAHP PVPYGQNPDL LQHAVYRAQP SSGTTNAQPR QTTRRYQSHK SRPAFVNKLW 180
SMLNDDSNTK LIQWAEDGKS FIVTNREEFV HQILPKYFKH SNFASFVRQL NMYGWHKVQD 240
VKSGSIQSSS DDKWQFENEN FIRGREDLLE KIIRQKGSSN NHNSPSGNGN PANGSNIPLD 300
NAAGSNNSNN NISSSNSFFN NGHLLQGKTL RLMNEANLGD KNDVTAILGE LEQIKYNQIA 360
ISKDLLRINK DNELLWQENM MARERHRTQQ QALEKMFRFL TSIVPHLDPK MIMDGLGDPK 420
VNNEKLNSAN NIGLNRDNTG TIDELKSNDS FINDDRNSFT NATTNARNNM SPNNDDNSID 480
TASTNTTNRK KNIDENIKNN NDIINDIIFN TNLANNLSNY NSNNNAGSPI RPYKQRYLLK 540
NRANSSTSSE NPSLTPFDIE SNNDRKISEI PFDDEEEEET DFRPFTSRDP NNQTSENTFD 600
PNRFTMLSDD DLKKDSHTND NKHNESDLFW DNVHRNIDEQ DARLQNLENM VHILSPGYPN 660
KSFNNKTSST NTNSNMESAV NVNSPGFNLQ DYLTGESNSP NSVHSVPSNG SGSTPLPMPN 720
DNDTEHASTS VNQGENGSGL TPFLTVDDHT LNDNNTSEGS TRVSPDIKFS ATENTKVSDN 780
LPSFNDHSYS TQADTAPENA KKRFVEEIPE PAIVEIQDPT EYNDHRLPKR AKK 834
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000232--HSF_DNA-bd
IPR027725--HSF_fam
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS00434--HSF_DOMAIN
Pfam

PF00447--HSF_DNA-bind
Gene Ontology

GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0032007--P:negative regulation of TOR signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0009408--P:response to heat
GO:0006351--P:transcription, DNA-templated