dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005356
Uniprot Accession P10614; CP51_YEAST; D3DKV1;
Genbank Protein ID NP_011871.1;
Genbank Nucleotide ID NM_001179137.1;
Protein Name Lanosterol 14-alpha demethylase
Protein Synonyms/Alias CYPLI;Cytochrome P450 51;Cytochrome P450-14DM;Cytochrome P450-LIA1;Sterol 14-alpha demethylase;
Gene Name ERG11
Gene Synonyms/Alias CYP51;YHR007C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
101VLLGRVMTVYLGPKGcurated19823750
103LGRVMTVYLGPKGHEcurated19823750
262DHAQKAISGTYMSLIcurated19823750
438WNKDSASSYSVGEEVcurated24961812
457GAISKGVSSPYLPFGPhosphoGRID 2.021126336
458AISKGVSSPYLPFGGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19060867; 19366988;
Sequence
(Fasta)		MSATKSIVGE ALEYVNIGLS HFLALPLAQR ISLIIIIPFI YNIVWQLLYS LRKDRPPLVF 60
YWIPWVGSAV VYGMKPYEFF EECQKKYGDI FSFVLLGRVM TVYLGPKGHE FVFNAKLADV 120
SAEAAYAHLT TPVFGKGVIY DCPNSRLMEQ KKFVKGALTK EAFKSYVPLI AEEVYKYFRD 180
SKNFRLNERT TGTIDVMVTQ PEMTIFTASR SLLGKEMRAK LDTDFAYLYS DLDKGFTPIN 240
FVFPNLPLEH YRKRDHAQKA ISGTYMSLIK ERRKNNDIQD RDLIDSLMKN STYKDGVKMT 300
DQEIANLLIG VLMGGQHTSA ATSAWILLHL AERPDVQQEL YEEQMRVLDG GKKELTYDLL 360
QEMPLLNQTI KETLRMHHPL HSLFRKVMKD MHVPNTSYVI PAGYHVLVSP GYTHLRDEYF 420
PNAHQFNIHR WNKDSASSYS VGEEVDYGFG AISKGVSSPY LPFGGGRHRC IGEHFAYCQL 480
GVLMSIFIRT LKWHYPEGKT VPPPDFTSMV TLPTGPAKII WEKRNPEQKI 531
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0349--Heme
KW-0408--Iron
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0479--Metal-binding
KW-0503--Monooxygenase
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001128--Cyt_P450
IPR017972--Cyt_P450_CS
IPR002403--Cyt_P450_E_grp-IV
PROSITE

PS00086--CYTOCHROME_P450
Pfam

PF00067--p450
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0020037--F:heme binding
GO:0005506--F:iron ion binding
GO:0008398--F:sterol 14-demethylase activity
GO:0070988--P:demethylation
GO:0006696--P:ergosterol biosynthetic process