dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005295
Uniprot Accession P10080; SSBP1_YEAST; D3DKT4;
Genbank Protein ID NP_011829.1;
Genbank Nucleotide ID NM_001179114.1;
Protein Name Single-stranded nucleic acid-binding protein
Protein Synonyms/Alias
Gene Name SBP1
Gene Synonyms/Alias SSB1;SSBR1;YHL034C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping. High-copy-number suppressor of decapping defects. Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations. Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies. Promotes translational repression of mRNA during glucose deprivation.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
2------MSAEIEEATPhosphoGRID 2.0;curated21126336; 22369663; 19823750; 24961812
16TNAVNNLSINDSEQQcurated24961812
91HALVKFPTKIDFDNIdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 19823750;
119IHIKRARTPGQMQRGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040406; 25315811
230QHTGRIFTSDSANRGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17287358; 19366988; 22369663;
231HTGRIFTSDSANRGMdbPTM 3.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
233GRIFTSDSANRGMAFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21177495; 19366988; 26040289;
242NRGMAFVTFSGENVDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988
244GMAFVTFSGENVDIEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900
268VFGDRELTVDVAVIRcurated22817900; 24961812
287EEEIEQETGSEEKQEcurated26040289; 22817900; 19823750; 24961812; 23825934; 20377248
289EIEQETGSEEKQE--dbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21081558; 19060867; 19366988;
Sequence
(Fasta)		MSAEIEEATN AVNNLSINDS EQQPRAPTHK TVIDPEDTIF IGNVAHECTE DDLKQLFVEE 60
FGDEVSVEIP IKEHTDGHIP ASKHALVKFP TKIDFDNIKE NYDTKVVKDR EIHIKRARTP 120
GQMQRGGFRG RGGFRGRGGF RGGFRGGYRG GFRGRGNFRG RGGARGGFNG QKREKIPLDQ 180
MERSKDTLYI NNVPFKATKE EVAEFFGTDA DSISLPMRKM RDQHTGRIFT SDSANRGMAF 240
VTFSGENVDI EAKAEEFKGK VFGDRELTVD VAVIRPENDE EEIEQETGSE EKQE 295
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0346--Stress response
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000932--C:cytoplasmic mRNA processing body
GO:0010494--C:cytoplasmic stress granule
GO:0005730--C:nucleolus
GO:0031370--F:eukaryotic initiation factor 4G binding
GO:0003729--F:mRNA binding
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0017148--P:negative regulation of translation
GO:0032055--P:negative regulation of translation in response to stress