dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005286
Uniprot Accession P10041; DL_DROME; Q6T3F7; Q6T3G1; Q6T3G7; Q6T3G8; Q6T3H0; Q6T3H3; Q6T3I3; Q6T3I5; Q6T3I7; Q6T3J1; Q6T3J2; Q6T3J3; Q6T3J4; Q6T3K0; Q6T3K1; Q6T3K9; Q6T3L5; Q6T3L7; Q6T3L9; Q6T3M2; Q6T3M4; Q6T3M7; Q6T3N1; Q6T3N3; Q6T3N5; Q6T3N7; Q6T4M9; Q6T4N0; Q6T4N1; Q6T4N2; Q6T4N3; Q6T4N4; Q6T4N6; Q95RM9; Q99108; Q9VDY2;
Genbank Protein ID NP_001247193.1; NP_477264.1; NP_732412.1;
Genbank Nucleotide ID NM_001260264.2; NM_057916.4; NM_169853.3;
Protein Name Neurogenic locus protein delta
Protein Synonyms/Alias
Gene Name Dl
Gene Synonyms/Alias CG3619;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
645NEQNAVATMHHNGSGcurated22817900
666SASLGGKTGSNSGLTdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
778AAEGKRISVLGEGSYdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES DGATGKCLGS 60
CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT DAQRFQNKGF TNPIQFPFSF 120
SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF 180
RVTCDLNYYG SGCAKFCRPR DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC 240
DKPNQCVCQL GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP 300
CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID EPHTKTGYKC 360
HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ GYQCECPIGY SGPNCDLQLD 420
NCSPNPCING GSCQPSGKCI CPAGFSGTRC ETNIDDCLGH QCENGGTCID MVNQYRCQCV 480
PGFHGTHCSS KVDLCLIRPC ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN 540
GGTCMNRVNS FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV 600
FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG SGVGVALASA 660
SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA AAAAAAADEC LMYGGYVASV 720
ADNNNANSDF CVAPLQRAKS QKQLNTDPTL MHRGSPAGSS AKGASGGGPG AAEGKRISVL 780
GEGSYCSQRW PSLAAAGVAG ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM 834
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
Interpro

IPR001774--DSL
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR011651--Notch_ligand_N
PROSITE

PS00010--ASX_HYDROXYL
PS51051--DSL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
Pfam

PF01414--DSL
PF00008--EGF
PF07657--MNNL
Gene Ontology

GO:0005912--C:adherens junction
GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0030139--C:endocytic vesicle
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0035003--C:subapical complex
GO:0005509--F:calcium ion binding
GO:0005112--F:Notch binding
GO:0005102--F:receptor binding
GO:0007015--P:actin filament organization
GO:0048800--P:antennal morphogenesis
GO:0007475--P:apposition of dorsal and ventral imaginal disc-derived wing surfaces
GO:0008356--P:asymmetric cell division
GO:0007298--P:border follicle cell migration
GO:0007155--P:cell adhesion
GO:0001708--P:cell fate specification
GO:0008407--P:chaeta morphogenesis
GO:0042676--P:compound eye cone cell fate commitment
GO:0048749--P:compound eye development
GO:0046667--P:compound eye retinal cell programmed cell death
GO:0007451--P:dorsal/ventral lineage restriction, imaginal disc
GO:0007398--P:ectoderm development
GO:0042067--P:establishment of ommatidial planar polarity
GO:0001736--P:establishment of planar polarity
GO:0030718--P:germ-line stem cell population maintenance
GO:0008347--P:glial cell migration
GO:0007480--P:imaginal disc-derived leg morphogenesis
GO:0036011--P:imaginal disc-derived leg segmentation
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0008586--P:imaginal disc-derived wing vein morphogenesis
GO:0007474--P:imaginal disc-derived wing vein specification
GO:0046331--P:lateral inhibition
GO:0007498--P:mesoderm development
GO:0035157--P:negative regulation of fusion cell fate specification
GO:0050768--P:negative regulation of neurogenesis
GO:0035155--P:negative regulation of terminal cell fate specification, open tracheal system
GO:0007399--P:nervous system development
GO:0007219--P:Notch signaling pathway
GO:0016318--P:ommatidial rotation
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0030720--P:oocyte localization involved in germarium-derived egg chamber formation
GO:0048477--P:oogenesis
GO:0007424--P:open tracheal system development
GO:0030707--P:ovarian follicle cell development
GO:0030713--P:ovarian follicle cell stalk formation
GO:0007422--P:peripheral nervous system development
GO:0008284--P:positive regulation of cell proliferation
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0007464--P:R3/R4 cell fate commitment
GO:0045465--P:R8 cell differentiation
GO:0007460--P:R8 cell fate commitment
GO:0045468--P:regulation of R8 cell spacing in compound eye
GO:0016330--P:second mitotic wave involved in compound eye morphogenesis
GO:0007423--P:sensory organ development
GO:0048863--P:stem cell differentiation
GO:0007419--P:ventral cord development
GO:0048190--P:wing disc dorsal/ventral pattern formation