dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005186
Uniprot Accession P0CT04; IPB2_YEAST; D6W1G3; P01095;
Genbank Protein ID NP_014383.1;
Genbank Nucleotide ID NM_001182854.1;
Protein Name Protease B inhibitor 2
Protein Synonyms/Alias Proteinase inhibitor I(B)2;
Gene Name PBI2
Gene Synonyms/Alias YNL015W;N2844;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
24EAKKFLDSVHHAGGScurated22369663
31SVHHAGGSIVHEFDIcurated22369663; 24961812
74EEDKEVHTN------PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated19684113; 19823750; 19779198; 19795423; 17330950; 19060867;
Sequence
(Fasta)		MTKNFIVTLK KNTPDVEAKK FLDSVHHAGG SIVHEFDIIK GYTIKVPDVL HLNKLKEKHN 60
DVIENVEEDK EVHTN 76
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0646--Protease inhibitor
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0722--Serine protease inhibitor
KW-0813--Transport
Interpro

IPR009020--Prot_inh_propept
IPR010259--S8pro/Inhibitor_I9
PROSITE
Pfam
Gene Ontology

GO:0000324--C:fungal-type vacuole
GO:0005634--C:nucleus
GO:0004866--F:endopeptidase inhibitor activity
GO:0004867--F:serine-type endopeptidase inhibitor activity
GO:0010951--P:negative regulation of endopeptidase activity
GO:0015031--P:protein transport
GO:0030162--P:regulation of proteolysis
GO:0042144--P:vacuole fusion, non-autophagic