dbPAF Protein Information
Tag | Content | ||||||||
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dbPAF ID | dbPAF-0005172 | ||||||||
Uniprot Accession | P0CG69; UBIQP_DROME; P68198; Q0E8I1; Q9VKW6; Q9VQX7; Q9VZL4; | ||||||||
Genbank Protein ID | NP_001261383.1; NP_523909.2; NP_728908.1; NP_995994.1; | ||||||||
Genbank Nucleotide ID | NM_001274454.1; NM_079185.4; NM_168043.3; NM_206272.1; | ||||||||
Protein Name | Polyubiquitin | ||||||||
Protein Synonyms/Alias | |||||||||
Gene Name | Ubi-p63E | ||||||||
Gene Synonyms/Alias | Ubi-m;CG11624; | ||||||||
Organism | Drosophila melanogaster(Fruit fly) | ||||||||
NCBI Taxa ID | 7227 | ||||||||
Functional Description (View all) |
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). | ||||||||
Phosphorylation Sites |
dbPAF PTMs: 1
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Sequence (Fasta) | MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60 IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI 120 FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA 180 KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT 240 ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR 300 LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL 360 SDYNIQKEST LHLVLRLRGG MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ 420 QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE 480 NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL 540 TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH 600 LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED 660 GRTLSDYNIQ KESTLHLVLR LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI 720 PPDQQRLIFA GKQLEDGRTL SDYNIQKEST LHLVLRLRGG IQA 764 |
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Keyword | KW-0181--Complete proteome |
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Interpro | IPR019956--Ubiquitin |
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PROSITE | |||||||||
Pfam | PF00240--ubiquitin |
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Gene Ontology | GO:0005829--C:cytosol |