dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005145
Uniprot Accession P0CF34; YL016_YEAST; P14771; Q12037; Q12065; Q6B0T5; Q6WV04;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Putative truncated guanine nucleotide exchange factor SDC25
Protein Synonyms/Alias
Gene Name SDC25
Gene Synonyms/Alias SCD25;YLL016W;L1309;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Promotes the exchange of Ras-bound GDP by GTP.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
4----MPITSSPDLFYcurated26040289
11TSSPDLFYLNDCDVVcurated26040289
19LNDCDVVYWYDLTRLcurated26040289
21DCDVVYWYDLTRLVCcurated26040289
24VVYWYDLTRLVCHYVcurated26040289
48NEREKFLTSLDLLTAcurated26040406
49EREKFLTSLDLLTAQcurated26040406
54LTSLDLLTAQITYVYcurated26040289
58DLLTAQITYVYMLFRcurated26040406
59LLTAQITYVYMLFRNcurated26040406
61TAQITYVYMLFRNLRcurated26040406
823SKRAKLLSHFIFIAEPhosphoPep 2.019060867
Sequence
(Fasta)		MPITSSPDLF YLNDCDVVYW YDLTRLVCHY VNLTERDLLA NEREKFLTSL DLLTAQITYV 60
YMLFRNLRLV EDSFKKTLKK LIYTLSRFSI NANIWFHSTL FEEREAIASQ KDPERRSPLL 120
QSILGTFQKF HFLLRLLHFL SNPNELTILP QLTPRFFKDS FNTISWNNPF LRKRLNQHMS 180
HDLPRQMIKA VAGASGIVAE NIDEIPASKQ GTSCSSETSH HSPSAPFQRR RRGTIFSNVS 240
GSSDESDTIW SKRKKPYPLN EETLSLVRAR KKQLDGKLKQ MIKSANEYLS NTANFSKMLN 300
FEMNFKTYEE VSGTIPIIDI LENLDLTIFL NLRELGDENR VFDEDVAIDD EDEEFLKHSL 360
SSLSYILSDY FNMKQYFHDV VVKFIIVAQH LTLEDPFVFS PMQNDLPTGY YEPMKPSSLN 420
LDNAKDKKNG SQNTDIQEEE DEYEPDPDSL ILFHNLINQD SDFNDLKFFN LAHVFKKSCD 480
DYFDVLKLAI EFVNQLILER ENLLNYAARM MKNNITELLL RGEEGYGSYD GGETAEKSDT 540
NAVYADSDTK DNDEWRDSQV KLPRYLQREY DSELIWGSNN RIKGGSKHAL ISYLTDNEKK 600
DLFFDITFLI TFRSIFTTTE FLSYLISQYN LDPPEDLCFE EYNEWVTKKL IPVKCRVVEI 660
MTTFFKQYWF LGYDEPDLAT LNLDYFAQVA IKENITGSVE LLKEVNQKFK HGNIQEATAP 720
MKTLDQQICQ DHYSGTLYST TESILAVDPV LFATQLTILE HEIYCEITIF DCLQKIWKNK 780
YTKSYGASPG LNEFISFANK LTNFISYSVV KEADKSKRAK LLSHFIFIAE YCRKFNNFSS 840
MTAIISALYS SPIYRLEKTW QAVIPQTRDL LQSLNKLMDP KKNFINYRNE LKSLHSAPCV 900
PFFGVYLSDL TFTDSGNPDY LVLEHGLKGV HDEKKYINFN KRSRLVDILQ EIIYFKKTHY 960
DFTKDRTVIE CISNSLENIP HIEKQYQLSL IIEPKPRKKV VPNSNSNNKS QEKSRDDQTD 1020
EGKTSTKKDR FPKFQLHKTK KKAPKVSK 1049
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
Interpro

IPR000651--Ras-like_Gua-exchang_fac_N
IPR019804--Ras_G-nucl-exch_fac_CS
IPR023578--Ras_GEF_dom
IPR001895--RASGEF_cat_dom
PROSITE

PS00720--RASGEF
PS50009--RASGEF_CAT
PS50212--RASGEF_NTER
Pfam

PF00617--RasGEF
PF00618--RasGEF_N
Gene Ontology

GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction