dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005000
Uniprot Accession P09959; SWI6_YEAST; D6VYI6;
Genbank Protein ID NP_013283.1;
Genbank Nucleotide ID NM_001182069.1;
Protein Name Regulatory protein SWI6
Protein Synonyms/Alias Cell-cycle box factor subunit SWI6;MBF subunit P90;Trans-acting activator of HO endonuclease gene;
Gene Name SWI6
Gene Synonyms/Alias YLR182W;L9470.8;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
133NKTKSENSKDNISSKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
149INNLQDMSLDSDAHRPhosphoGRID 2.0;UniProt;curated19823750; 19779198; 19795423; 12724400; 26040289; 22817900;
152LQDMSLDSDAHRELGPhosphoGRID 2.0;curated19823750; 19779198; 19795423; 12724400; 26040289; 22817900;
160DAHRELGSPLKKLKIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated14993267; 17287358; 17563356; 16381945; 23193290; 19823750;
169LKKLKIDTSVIDAESdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 21126336; 19366988; 22369663;
170KKLKIDTSVIDAESDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 12724400; 19366988
176TSVIDAESDSTPNTAdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 21081558; 19060867;
178VIDAESDSTPNTARGdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 20702584; 19779198;
179IDAESDSTPNTARGKdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 21081558; 19060867;
182ESDSTPNTARGKPNDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19779198; 21081558; 19060867;
196DDINKGPSGDNENNGcurated25315811
204GDNENNGTDDNDRTAcurated25315811
228LTSDFLSSPLKIMKAdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
238KIMKALPSPVVNDNEPhosphoGRID 2.0;curated20219973; 25315811
267PEIQEMPTSLNNDSSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
268EIQEMPTSLNNDSSNPhosphoGRID 2.012724400
547GKAKKIRSQLLKNPPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 12724400; 19366988; 22817900;
557LKNPPETTSLINDVQPhosphoGRID 2.012724400
636GIEEEEESFREESKKcurated24961812
715LPAEKIQSMLPPTVLPhosphoGRID 2.012724400
Sequence
(Fasta)		MALEEVVRYL GPHNEIPLTL TRDSETGHFL LKHFLPILQQ YHDTGNINET NPDSFPTDEE 60
RNKLLAHYGI AVNTDDRGEL WIELEKCLQL LNMLNLFGLF QDAFEFEEPE TDQDEEDPSH 120
SKLPENKTKS ENSKDNISSK RINNLQDMSL DSDAHRELGS PLKKLKIDTS VIDAESDSTP 180
NTARGKPNDD INKGPSGDNE NNGTDDNDRT AGPIITFTHD LTSDFLSSPL KIMKALPSPV 240
VNDNEQKMKL EAFLQRLLFP EIQEMPTSLN NDSSNRNSEG GSSNQQQQHV SFDSLLQEVN 300
DAFPNTQLNL NIPVDEHGNT PLHWLTSIAN LELVKHLVKH GSNRLYGDNM GESCLVKAVK 360
SVNNYDSGTF EALLDYLYPC LILEDSMNRT ILHHIIITSG MTGCSAAAKY YLDILMGWIV 420
KKQNRPIQSG TNEKESKPND KNGERKDSIL ENLDLKWIIA NMLNAQDSNG DTCLNIAARL 480
GNISIVDALL DYGADPFIAN KSGLRPVDFG AGTSKLQNTN GGDENSKMVS KGDYDGQKNG 540
KAKKIRSQLL KNPPETTSLI NDVQNLLNSI SKDYENETVQ YNEKLEKLHK ELNEQREELA 600
NSREQLANVK QLKDEYSLMQ EQLTNLKAGI EEEEESFREE SKKLGIIADE SSGIDWDSSE 660
YDADEPFKVE FLSDFLEDKL QKNYEGDISK LLEAESKEQI MEQIRNQLPA EKIQSMLPPT 720
VLLKARINAY KRNDKHLTNV LDTISTKQSE LENKFRRVLS LCLKIDENKV DNMLDGLLQA 780
ISSEDPQDID TDEMQDFLKK HAS 804
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR032468--Swi6
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030907--C:MBF transcription complex
GO:0005634--C:nucleus
GO:0033309--C:SBF transcription complex
GO:0003677--F:DNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061408--P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0071931--P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle