dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004997
Uniprot Accession P09950; HEM1_YEAST; D6VSL3; E9P946;
Genbank Protein ID NP_010518.1;
Genbank Nucleotide ID NM_001180540.1;
Protein Name 5-aminolevulinate synthase, mitochondrial
Protein Synonyms/Alias 5-aminolevulinic acid synthase;Delta-ALA synthase;Delta-aminolevulinate synthase;
Gene Name HEM1
Gene Synonyms/Alias CYD1;YDR232W;YD9934.16;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
23VSTLNRLSTTAAPHAcurated22817900
24STLNRLSTTAAPHAKcurated22817900
25TLNRLSTTAAPHAKNcurated22817900
Sequence
(Fasta)		MQRSIFARFG NSSAAVSTLN RLSTTAAPHA KNGYATATGA GAAAATATAS STHAAAAAAA 60
AANHSTQESG FDYEGLIDSE LQKKRLDKSY RYFNNINRLA KEFPLAHRQR EADKVTVWCS 120
NDYLALSKHP EVLDAMHKTI DKYGCGAGGT RNIAGHNIPT LNLEAELATL HKKEGALVFS 180
SCYVANDAVL SLLGQKMKDL VIFSDELNHA SMIVGIKHAN VKKHIFKHND LNELEQLLQS 240
YPKSVPKLIA FESVYSMAGS VADIEKICDL ADKYGALTFL DEVHAVGLYG PHGAGVAEHC 300
DFESHRASGI ATPKTNDKGG AKTVMDRVDM ITGTLGKSFG SVGGYVAASR KLIDWFRSFA 360
PGFIFTTTLP PSVMAGATAA IRYQRCHIDL RTSQQKHTMY VKKAFHELGI PVIPNPSHIV 420
PVLIGNADLA KQASDILINK HQIYVQAINF PTVARGTERL RITPTPGHTN DLSDILINAV 480
DDVFNELQLP RVRDWESQGG LLGVGESGFV EESNLWTSSQ LSLTNDDLNP NVRDPIVKQL 540
EVSSGIKQ 549
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0496--Mitochondrion
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0809--Transit peptide
Interpro

IPR010961--4pyrrol_synth_NH2levulA_synth
IPR001917--Aminotrans_II_pyridoxalP_BS
IPR004839--Aminotransferase_I/II
IPR015424--PyrdxlP-dep_Trfase
IPR015421--PyrdxlP-dep_Trfase_major_sub1
IPR015422--PyrdxlP-dep_Trfase_major_sub2
PROSITE

PS00599--AA_TRANSFER_CLASS_2
Pfam

PF00155--Aminotran_1_2
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0003870--F:5-aminolevulinate synthase activity
GO:0030170--F:pyridoxal phosphate binding
GO:0006783--P:heme biosynthetic process
GO:0006782--P:protoporphyrinogen IX biosynthetic process