dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004996
Uniprot Accession P09938; RIR2_YEAST; D6VWF6;
Genbank Protein ID NP_012508.1;
Genbank Nucleotide ID NM_001181460.1;
Protein Name Ribonucleoside-diphosphate reductase small chain 1
Protein Synonyms/Alias Ribonucleotide reductase R2 subunit 1;Ribonucleotide reductase small subunit 1;
Gene Name RNR2
Gene Synonyms/Alias CRT6;YJL026W;J1271;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
5---MPKETPSKAAADPhosphoPep 2.0;curated19060867; 23825934
7-MPKETPSKAAADALdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
15KAAADALSDLEIKDSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated12872131; 15665377; 17330950; 17563356; 18407956; 16381945;
22SDLEIKDSKSNLNKEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19823750; 19779198;
24LEIKDSKSNLNKELEdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
41REENRVKSDMLKEKLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 16381945; 23193290; 19366988; 22817900; 25315811;
374NFFEKRVSDYQKAGVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 22817900;
394KQEAGAFTFNEDF--curated19547744
Sequence
(Fasta)		MPKETPSKAA ADALSDLEIK DSKSNLNKEL ETLREENRVK SDMLKEKLSK DAENHKAYLK 60
SHQVHRHKLK EMEKEEPLLN EDKERTVLFP IKYHEIWQAY KRAEASFWTA EEIDLSKDIH 120
DWNNRMNENE RFFISRVLAF FAASDGIVNE NLVENFSTEV QIPEAKSFYG FQIMIENIHS 180
ETYSLLIDTY IKDPKESEFL FNAIHTIPEI GEKAEWALRW IQDADALFGE RLVAFASIEG 240
VFFSGSFASI FWLKKRGMMP GLTFSNELIC RDEGLHTDFA CLLFAHLKNK PDPAIVEKIV 300
TEAVEIEQRY FLDALPVALL GMNADLMNQY VEFVADRLLV AFGNKKYYKV ENPFDFMENI 360
SLAGKTNFFE KRVSDYQKAG VMSKSTKQEA GAFTFNEDF
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR009078--Ferritin-like_SF
IPR012348--RNR-rel
IPR000358--RNR_small
IPR030475--RNR_small_AS
PROSITE

PS00368--RIBORED_SMALL
Pfam

PF00268--Ribonuc_red_sm
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005971--C:ribonucleoside-diphosphate reductase complex
GO:0046872--F:metal ion binding
GO:0004748--F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0009186--P:deoxyribonucleoside diphosphate metabolic process
GO:0009263--P:deoxyribonucleotide biosynthetic process
GO:0006260--P:DNA replication