| Tag |
Content |
| dbPAF ID |
dbPAF-0004951 |
| Uniprot Accession |
P09624; DLDH_YEAST; D6VTL1;
|
| Genbank Protein ID |
NP_116635.1;
|
| Genbank Nucleotide ID |
NM_001179948.1;
|
| Protein Name |
Dihydrolipoyl dehydrogenase, mitochondrial |
| Protein Synonyms/Alias |
Dihydrolipoamide dehydrogenase;Glycine decarboxylase complex subunit L;Lipoamide dehydrogenase component of pyruvate dehydrogenase complex;Pyruvate dehydrogenase complex E3 component; |
| Gene Name |
LPD1 |
| Gene Synonyms/Alias |
DHLP1;YFL018C; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine.Functional Description
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 418 | KFPFAANSRAKTNQD | curated | 22369663 |
|
Sequence
(Fasta) | MLRIRSLLNN KRAFSSTVRT LTINKSHDVV IIGGGPAGYV AAIKAAQLGF NTACVEKRGK 60
LGGTCLNVGC IPSKALLNNS HLFHQMHTEA QKRGIDVNGD IKINVANFQK AKDDAVKQLT 120
GGIELLFKKN KVTYYKGNGS FEDETKIRVT PVDGLEGTVK EDHILDVKNI IVATGSEVTP 180
FPGIEIDEEK IVSSTGALSL KEIPKRLTII GGGIIGLEMG SVYSRLGSKV TVVEFQPQIG 240
ASMDGEVAKA TQKFLKKQGL DFKLSTKVIS AKRNDDKNVV EIVVEDTKTN KQENLEAEVL 300
LVAVGRRPYI AGLGAEKIGL EVDKRGRLVI DDQFNSKFPH IKVVGDVTFG PMLAHKAEEE 360
GIAAVEMLKT GHGHVNYNNI PSVMYSHPEV AWVGKTEEQL KEAGIDYKIG KFPFAANSRA 420
KTNQDTEGFV KILIDSKTER ILGAHIIGPN AGEMIAEAGL ALEYGASAED VARVCHAHPT 480
LSEAFKEANM AAYDKAIHC
Fasta Sequence
>P09624|LPD1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0274--FAD
KW-0285--Flavoprotein
KW-0496--Mitochondrion
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0676--Redox-active center
KW-1185--Reference proteome
KW-0809--Transit peptide
|
| Interpro |
IPR023753--FAD/NAD-binding_dom
IPR016156--FAD/NAD-linked_Rdtase_dimer
IPR006258--Lipoamide_DH
IPR004099--Pyr_nucl-diS_OxRdtase_dimer
IPR012999--Pyr_OxRdtase_I_AS
|
| PROSITE |
PS00076--PYRIDINE_REDOX_1
|
| Pfam |
PF07992--Pyr_redox_2
PF02852--Pyr_redox_dim
|
| Gene Ontology |
GO:0005960--C:glycine cleavage complex
GO:0042645--C:mitochondrial nucleoid
GO:0009353--C:mitochondrial oxoglutarate dehydrogenase complex
GO:0005967--C:mitochondrial pyruvate dehydrogenase complex
GO:0004148--F:dihydrolipoyl dehydrogenase activity
GO:0050660--F:flavin adenine dinucleotide binding
GO:0004375--F:glycine dehydrogenase (decarboxylating) activity
GO:0004591--F:oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0004738--F:pyruvate dehydrogenase activity
GO:0006103--P:2-oxoglutarate metabolic process
GO:0045454--P:cell redox homeostasis
GO:0006546--P:glycine catabolic process
GO:0042743--P:hydrogen peroxide metabolic process
GO:0006550--P:isoleucine catabolic process
GO:0006564--P:L-serine biosynthetic process
GO:0006552--P:leucine catabolic process
GO:0006090--P:pyruvate metabolic process
GO:0006574--P:valine catabolic process
|
