dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004939
Uniprot Accession P09547; SWI1_YEAST; D6W3Z6;
Genbank Protein ID NP_015309.1;
Genbank Nucleotide ID NM_001183830.2;
Protein Name SWI/SNF chromatin-remodeling complex subunit SWI1
Protein Synonyms/Alias Regulatory protein GAM3;SWI/SNF complex subunit SWI1;Transcription regulatory protein ADR6;Transcription regulatory protein SWI1;
Gene Name SWI1
Gene Synonyms/Alias ADR6;GAM3;YPL016W;LPA1;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
152SPYDSNNSNTNLNSLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
154YDSNNSNTNLNSLSPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
160NTNLNSLSPQAILAKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
269NSMDRSSSASNEFVPPhosphoPep 2.019060867
576NTPKSLNSNININVNcurated24961812
656LKKLPKVYKRSIVRNPhosphoGRID 2.021126336
808EKVNNNATLTPNDSNPhosphoGRID 2.021126336
810VNNNATLTPNDSNDEPhosphoGRID 2.0;curated19823750; 19795423; 26040289; 22369663; 22817900; 25315811
1169FEISENNSDSNSNNNcurated24961812
Sequence
(Fasta)		MDFFNLNNNN NNNNTTTTTT TTNNNNTNNN NTNNNNNPAN NTNNNNSTGH SSNTNNNTNN 60
NNTNTGASGV DDFQNFFDPK PFDQNLDSNN NNSNSNNNDN NNSNTVASST NFTSPTAVVN 120
NAAPANVTGG KAANFIQNQS PQFNSPYDSN NSNTNLNSLS PQAILAKNSI IDSSNLPLQA 180
QQQLYGGNNN NNSTGIANDN VITPHFITNV QSISQNSSSS TPNTNSNSTP NANQQFLPFN 240
NSASNNGNLT SNQLISNYAA SNSMDRSSSA SNEFVPNTSD NNNNSNNHNM RNNSNNKTSN 300
NNNVTAVPAA TPANTNNSTS NANTVFSERA AMFAALQQKQ QQRFQALQQQ QQQQQNQQQQ 360
NQQPQQQQQQ QQNPKFLQSQ RQQQQRSILQ SLNPALQEKI STELNNKQYE LFMKSLIENC 420
KKRNMPLQSI PEIGNRKINL FYLYMLVQKF GGADQVTRTQ QWSMVAQRLQ ISDYQQLESI 480
YFRILLPYER HMISQEGIKE TQAKRIFLQQ FLQELLKKVQ QQQQAAALAN ANNNINSASS 540
APTPAAPGAS VPATAAPGTE AGIVPVSANT PKSLNSNINI NVNNNNIGQQ QVKKPRKQRV 600
KKKTKKELEL ERKEREDFQK RQQKLLEDQQ RQQKLLLETK LRQQYEIELK KLPKVYKRSI 660
VRNYKPLINR LKHYNGYDIN YISKIGEKID SNKPIFLFAP ELGAINLHAL SMSLQSKNLG 720
EINTALNTLL VTSADSNLKI SLVKYPELLD SLAILGMNLL SNLSQNVVPY HRNTSDYYYE 780
DAGSNQYYVT QHDKMVDKIF EKVNNNATLT PNDSNDEKVT ILVDSLTGNQ LPTPTPTEME 840
PDLDTECFIS MQSTSPAVKQ WDLLPEPIRF LPNQFPLKIH RTPYLTSLKK IKDEIDDPFT 900
KINTRGAEDP KVLINDQLST ISMILRNISF SDNNSRIMSR NFYLKRFISD LLWLVLIHPE 960
NFTCNRKILN FKKDLVIVLS NISHLLEIAS SIDCLLILIL VISFGQPKLN PMASSSSFGS 1020
ESLTFNEFQL QWGKYQTFGV DILAKLFSLE KPNLNYFKSI LLNKNTGNNL YDRNSNNNHK 1080
DKKLLRRLLN LYNDNNKNNN NRHNLLNDVV SFLFSAIPLQ QVLSQSADPS LLIDQFSPVI 1140
SQSLTSILVI VQKILPLSNE VFEISENNSD SNSNNNGNKD SSFNFNKNLP FVWLSSEENI 1200
GSGLLKLSEI ILNINNSTSK NTLLQQQNYS KVLLPSINIS CVQLIKCLVE KSICFENCLN 1260
NDPEILKKIA SIPNLFPTDL EIFQLFTNPS VDIQIINQYQ LLYNLKNDIL TNLE 1315
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0034--Amyloid
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0640--Prion
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
PROSITE

PS51011--ARID
Pfam

PF01388--ARID
Gene Ontology

GO:0005634--C:nucleus
GO:0016514--C:SWI/SNF complex
GO:0046872--F:metal ion binding
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0000436--P:carbon catabolite activation of transcription from RNA polymerase II promoter
GO:0044109--P:cellular alcohol catabolic process
GO:0006261--P:DNA-dependent DNA replication
GO:0031496--P:positive regulation of mating type switching
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061412--P:positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation
GO:0005987--P:sucrose catabolic process
GO:0006351--P:transcription, DNA-templated