dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004915
Uniprot Accession P09440; C1TM_YEAST; D6VQ83;
Genbank Protein ID NP_009640.1;
Genbank Nucleotide ID NM_001178432.1;
Protein Name C-1-tetrahydrofolate synthase, mitochondrial
Protein Synonyms/Alias
Gene Name MIS1
Gene Synonyms/Alias YBR084W;YBR0751;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
27RIYRLKVSPTVHASQcurated22817900
29YRLKVSPTVHASQYHcurated22817900
39ASQYHILSGRKLAQScurated22817900
289VGDVDFDSVKEKTSYPhosphoGRID 2.0;curated19823750; 19795423; 22817900
351VPSDIDISRAQSPKHcurated20377248
355IDISRAQSPKHIKQVcurated22817900; 20377248
519KKGIRKFTPSMQRRLPhosphoGRID 2.019779198
521GIRKFTPSMQRRLKRdbPTM 3.018407956; 16381945; 23193290
540KEDPDALTPEEVKRFcurated22817900
802VAINRFETDSQAEIEPhosphoGRID 2.0;curated19779198; 22817900
804INRFETDSQAEIEVIPhosphoGRID 2.0;curated19779198; 22817900
Sequence
(Fasta)		MLSRLSLLSN SRAFQQARWR IYRLKVSPTV HASQYHILSG RKLAQSIREK ANDEIQAIKL 60
KHPNFKPTLK IIQVGARPDS STYVRMKLKA SKDSNVDCII EKLPAEITEV ELLKKISDIN 120
DDDSIHGLLI QLPLPRHLDE TTITNAVDFK KDVDGFHRYN AGELAKKGGK PYFIPCTPYG 180
CMKLLEEAHV KLDGKNAVVL GRSSIVGNPI ASLLKNANAT VTVCHSHTRN IAEVVSQADI 240
VIAACGIPQY VKSDWIKEGA VVIDVGINYV PDISKKSGQK LVGDVDFDSV KEKTSYITPV 300
PGGVGPMTVA MLVSNVLLAA KRQFVESEKL PVIKPLPLHL ESPVPSDIDI SRAQSPKHIK 360
QVAEELGIHS HELELYGHYK AKISPNIFKR LESRENGKYV LVAGITPTPL GEGKSTTTMG 420
LVQALSAHLG KPSIANVRQP SLGPTLGVKG GAAGGGYAQV IPMDEFNLHL TGDIHAISAA 480
NNLLAAAIDT RMFHEATQKN DSTFYKRLVP RKKGIRKFTP SMQRRLKRLD IEKEDPDALT 540
PEEVKRFARL NINPDTITIR RVVDINDRML RQITIGEAAT EKGFTRTTGF DITVASELMA 600
ILALSKSLHE MKERIGRMVI GADYDNKPVT VEDIGCTGAL TALLRDAIKP NLMQTLEGTP 660
VMVHAGPFAN ISIGASSVIA DLMALKLVGS EKNPLNDKNI HEPGYVVTEA GFDFAMGGER 720
FFDIKCRSSG LVPDAVVLVA TVRALKSHGG APNVKPGQSL PKEYTEENID FVAKGVSNLV 780
KQIENIKTFG IPVVVAINRF ETDSQAEIEV IKKAALNAGA SHAVTSNHWM EGGKGAVELA 840
HAVVDATKEP KNFNFLYDVN SSIEDKLTSI VQKMYGGAKI EVSPEAQKKI DTYKKQGFGN 900
LPICIAKTQY SLSHDPSLKG VPRGFTFPIR DVRASIGAGY LYALAAEIQT IPGLSTYAGY 960
MAVEVDDDGE IEGLF 976
Keyword

KW-0028--Amino-acid biosynthesis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0368--Histidine biosynthesis
KW-0378--Hydrolase
KW-0436--Ligase
KW-0486--Methionine biosynthesis
KW-0496--Mitochondrion
KW-0511--Multifunctional enzyme
KW-0521--NADP
KW-0547--Nucleotide-binding
KW-0554--One-carbon metabolism
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR000559--Formate_THF_ligase
IPR020628--Formate_THF_ligase_CS
IPR016040--NAD(P)-bd_dom
IPR027417--P-loop_NTPase
IPR000672--THF_DH/CycHdrlase
IPR020630--THF_DH/CycHdrlase_cat_dom
IPR020867--THF_DH/CycHdrlase_CS
IPR020631--THF_DH/CycHdrlase_NAD-bd_dom
PROSITE

PS00721--FTHFS_1
PS00722--FTHFS_2
PS00766--THF_DHG_CYH_1
PS00767--THF_DHG_CYH_2
Pfam

PF01268--FTHFS
PF00763--THF_DHG_CYH
PF02882--THF_DHG_CYH_C
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0004329--F:formate-tetrahydrofolate ligase activity
GO:0004477--F:methenyltetrahydrofolate cyclohydrolase activity
GO:0004488--F:methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0046656--P:folic acid biosynthetic process
GO:0000105--P:histidine biosynthetic process
GO:0009086--P:methionine biosynthetic process
GO:0006139--P:nucleobase-containing compound metabolic process
GO:0006730--P:one-carbon metabolic process
GO:0006164--P:purine nucleotide biosynthetic process
GO:0035999--P:tetrahydrofolate interconversion