dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004889
Uniprot Accession P09208; INSR_DROME; B7Z0N6; Q24023; Q24089; Q9VD94;
Genbank Protein ID NP_001138093.1; NP_001138094.1; NP_001138095.1; NP_524436.2;
Genbank Nucleotide ID NM_001144621.3; NM_001144622.2; NM_001144623.2; NM_079712.6;
Protein Name Insulin-like receptor
Protein Synonyms/Alias
Gene Name InR
Gene Synonyms/Alias dinr;Dir-a;Inr-a;CG18402;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
120KKRDVKCSGHQCSNEcurated22817900
125KCSGHQCSNECDDGScurated22817900
133NECDDGSTKNNRQQRcurated22817900
1109LRHVRSITDDTDAFFcurated22817900
1816STGGGKLSGEQHLLPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;UniProt;curated18327897; 16381945; 23193290; 21081558; 22817900
2100SVSQTRKSPTNPNSGPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
2102SQTRKSPTNPNSGIGPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
Sequence
(Fasta)		MFNMPRGVTK SKSKRGKIKM ENDMAAAATT TACTLGHICV LCRQEMLLDT CCCRQAVEAV 60
DSPASSEEAY SSSNSSSCQA SSEISAEEVW FLSHDDIVLC RRPKFDEVET TGKKRDVKCS 120
GHQCSNECDD GSTKNNRQQR ENFNIFSNCH NILRTLQSLL LLMFNCGIFN KRRRRQHQQQ 180
HHHHYQHHHQ QHHQQHHQRQ QANVSYTKFL LLLQTLAAAT TRLSLSPKNY KQQQQLQHNQ 240
QLPRATPQQK QQEKDRHKCF HYKHNYSYSP GISLLLFILL ANTLAIQAVV LPAHQQHLLH 300
NDIADGLDKT ALSVSGTQSR WTRSESNPTM RLSQNVKPCK SMDIRNMVSH FNQLENCTVI 360
EGFLLIDLIN DASPLNRSFP KLTEVTDYII IYRVTGLHSL SKIFPNLSVI RGNKLFDGYA 420
LVVYSNFDLM DLGLHKLRSI TRGGVRIEKN HKLCYDRTID WLEILAENET QLVVLTENGK 480
EKECRLSKCP GEIRIEEGHD TTAIEGELNA SCQLHNNRRL CWNSKLCQTK CPEKCRNNCI 540
DEHTCCSQDC LGGCVIDKNG NESCISCRNV SFNNICMDSC PKGYYQFDSR CVTANECITL 600
TKFETNSVYS GIPYNGQCIT HCPTGYQKSE NKRMCEPCPG GKCDKECSSG LIDSLERARE 660
FHGCTIITGT EPLTISIKRE SGAHVMDELK YGLAAVHKIQ SSLMVHLTYG LKSLKFFQSL 720
TEISGDPPMD ADKYALYVLD NRDLDELWGP NQTVFIRKGG VFFHFNPKLC VSTINQLLPM 780
LASKPKFFEK SDVGADSNGN RGSCGTAVLN VTLQSVGANS AMLNVTTKVE IGEPQKPSNA 840
TIVFKDPRAF IGFVFYHMID PYGNSTKSSD DPCDDRWKVS SPEKSGVMVL SNLIPYTNYS 900
YYVRTMAISS ELTNAESDVK NFRTNPGRPS KVTEVVATAI SDSKINVTWS YLDKPYGVLT 960
RYFIKAKLIN RPTRNNNRDY CTEPLVKAME NDLPATTPTK KISDPLAGDC KCVEGSKKTS 1020
SQEYDDRKVQ AGMEFENALQ NFIFVPNIRK SKNGSSDKSD GAEGAALDSN AIPNGGATNP 1080
SRRRRDVALE PELDDVEGSV LLRHVRSITD DTDAFFEKDD ENTYKDEEDL SSNKQFYEVF 1140
AKELPPNQTH FVFEKLRHFT RYAIFVVACR EEIPSEKLRD TSFKKSLCSD YDTVFQTTKR 1200
KKFADIVMDL KVDLEHANNT ESPVRVRWTP PVDPNGEIVT YEVAYKLQKP DQVEEKKCIP 1260
AADFNQTAGY LIKLNEGLYS FRVRANSIAG YGDFTEVEHI KVEPPPSYAK VFFWLLGIGL 1320
AFLIVSLFGY VCYLHKRKVP SNDLHMNTEV NPFYASMQYI PDDWEVLREN IIQLAPLGQG 1380
SFGMVYEGIL KSFPPNGVDR ECAIKTVNEN ATDRERTNFL SEASVMKEFD TYHVVRLLGV 1440
CSRGQPALVV MELMKKGDLK SYLRAHRPEE RDEAMMTYLN RIGVTGNVQP PTYGRIYQMA 1500
IEIADGMAYL AAKKFVHRDL AARNCMVADD LTVKIGDFGM TRDIYETDYY RKGTKGLLPV 1560
RWMPPESLRD GVYSSASDVF SFGVVLWEMA TLAAQPYQGL SNEQVLRYVI DGGVMERPEN 1620
CPDFLHKLMQ RCWHHRSSAR PSFLDIIAYL EPQCPNSQFK EVSFYHSEAG LQHREKERKE 1680
RNQLDAFAAV PLDQDLQDRE QQEDATTPLR MGDYQQNSSL DQPPESPIAM VDDQGSHLPF 1740
SLPSGFIASS TPDGQTVMAT AFQNIPAAQG DISATYVVPD ADALDGDRGY EIYDPSPKCA 1800
ELPTSRSGST GGGKLSGEQH LLPRKGRQPT IMSSSMPDDV IGGSSLQPST ASAGSSNASS 1860
HTGRPSLKKT VADSVRNKAN FINRHLFNHK RTGSNASHKS NASNAPSTSS NTNLTSHPVA 1920
MGNLGTIESG GSGSAGSYTG TPRFYTPSAT PGGGSGMAIS DNPNYRLLDE SIASEQATIL 1980
TTSSPNPNYE MMHPPTSLVS TNPNYMPMNE TPVQMAGVTI SHNPNYQPMQ APLNARQSQS 2040
SSDEDNEQEE DDEDEDDDVD DEHVEHIKME RMPLSRPRQR ALPSKTQPPR SRSVSQTRKS 2100
PTNPNSGIGA TGAGNRSNLL KENWLRPAST PRPPPPNGFI GREA 2145
Keyword

KW-0067--ATP-binding
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0341--Growth regulation
KW-0418--Kinase
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0829--Tyrosine-protein kinase
Interpro

IPR003961--FN3_dom
IPR006211--Furin-like_Cys-rich_dom
IPR006212--Furin_repeat
IPR009030--Growth_fac_rcpt_N_dom
IPR013783--Ig-like_fold
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR000494--Rcpt_L-dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR002011--Tyr_kinase_rcpt_2_CS
PROSITE

PS50853--FN3
PS01352--HEMATOPO_REC_L_F1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS00239--RECEPTOR_TYR_KIN_II
Pfam

PF00757--Furin-like
PF07714--Pkinase_Tyr
PF01030--Recep_L_domain
Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005899--C:insulin receptor complex
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0043559--F:insulin binding
GO:0043560--F:insulin receptor substrate binding
GO:0005009--F:insulin-activated receptor activity
GO:0046872--F:metal ion binding
GO:0043548--F:phosphatidylinositol 3-kinase binding
GO:0004713--F:protein tyrosine kinase activity
GO:0007568--P:aging
GO:0007411--P:axon guidance
GO:0005975--P:carbohydrate metabolic process
GO:0016049--P:cell growth
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007623--P:circadian rhythm
GO:0008340--P:determination of adult lifespan
GO:0048589--P:developmental growth
GO:0007391--P:dorsal closure
GO:0009790--P:embryo development
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0048132--P:female germ-line stem cell asymmetric division
GO:0008585--P:female gonad development
GO:0060180--P:female mating behavior
GO:0007390--P:germ-band shortening
GO:0060250--P:germ-line stem-cell niche homeostasis
GO:0040007--P:growth
GO:0007446--P:imaginal disc growth
GO:0008286--P:insulin receptor signaling pathway
GO:0036335--P:intestinal stem cell homeostasis
GO:0006629--P:lipid metabolic process
GO:0007626--P:locomotory behavior
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0035264--P:multicellular organism growth
GO:0007520--P:myoblast fusion
GO:0010507--P:negative regulation of autophagy
GO:0042321--P:negative regulation of circadian sleep/wake cycle, sleep
GO:2000252--P:negative regulation of feeding behavior
GO:0090278--P:negative regulation of peptide hormone secretion
GO:0007399--P:nervous system development
GO:0016322--P:neuron remodeling
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030307--P:positive regulation of cell growth
GO:0008284--P:positive regulation of cell proliferation
GO:0045793--P:positive regulation of cell size
GO:0040018--P:positive regulation of multicellular organism growth
GO:0046622--P:positive regulation of organ growth
GO:0007285--P:primary spermatocyte growth
GO:0046777--P:protein autophosphorylation
GO:0051290--P:protein heterotetramerization
GO:0006468--P:protein phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0008361--P:regulation of cell size
GO:0040014--P:regulation of multicellular organism growth
GO:0046620--P:regulation of organ growth
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0034059--P:response to anoxia
GO:0042220--P:response to cocaine
GO:0007584--P:response to nutrient
GO:0006979--P:response to oxidative stress
GO:0007525--P:somatic muscle development
GO:0007296--P:vitellogenesis