dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004881
Uniprot Accession P09119; CDC6_YEAST; D6VVZ7;
Genbank Protein ID NP_012341.1;
Genbank Nucleotide ID NM_001181627.1;
Protein Name Cell division control protein 6
Protein Synonyms/Alias
Gene Name CDC6
Gene Synonyms/Alias YJL194W;J0347;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
7-MSAIPITPTKRIRRPhosphoGRID 2.017130241; 11572976; 10512865; 17267692
23LFDDAPATPPRPLKRPhosphoGRID 2.017130241; 10734126; 11572976; 10512865; 17267692
39KLQFTDVTPESSPEKPhosphoGRID 2.010734126; 17267692
43TDVTPESSPEKLQFGPhosphoGRID 2.017130241; 10734126; 11572976; 10512865; 17267692
128IIRQKFQSLPLSLSTPhosphoGRID 2.019779198
135SLPLSLSTPRSKDVLPhosphoGRID 2.010734126; 17267692
354LEKRFLLSPTRGSLNPhosphoGRID 2.010734126; 17267692
368NSAQVPLTPTTSPVKPhosphoGRID 2.0;UniProt;curated10734126; 19779198; 11532947; 17267692; 22817900
370AQVPLTPTTSPVKKSPhosphoGRID 2.017130241
371QVPLTPTTSPVKKSYPhosphoGRID 2.017130241
372VPLTPTTSPVKKSYPPhosphoGRID 2.017130241; 10734126; 19779198; 10512865; 11532947; 17267692
395NYIAKVFSKFVNNNScurated22817900
Sequence
(Fasta)		MSAIPITPTK RIRRNLFDDA PATPPRPLKR KKLQFTDVTP ESSPEKLQFG SQSIFLRTKA 60
LLQKSSELVN LNSSDGALPA RTAEYEQVMN FLAKAISEHR SDSLYITGPP GTGKTAQLDM 120
IIRQKFQSLP LSLSTPRSKD VLRHTNPNLQ NLSWFELPDG RLESVAVTSI NCISLGEPSS 180
IFQKIFDSFQ DLNGPTLQIK NMQHLQKFLE PYHKKTTFVV VLDEMDRLLH ANTSETQSVR 240
TILELFLLAK LPTVSFVLIG MANSLDMKDR FLSRLNLDRG LLPQTIVFQP YTAEQMYEIV 300
IQKMSSLPTI IFQPMAIKFA AKKCAGNTGD LRKLFDVLRG SIEIYELEKR FLLSPTRGSL 360
NSAQVPLTPT TSPVKKSYPE PQGKIGLNYI AKVFSKFVNN NSTRTRIAKL NIQQKLILCT 420
IIQSLKLNSD ATIDESFDHY IKAITKTDTL APLQRNEFLE ICTILETCGL VSIKKTKCKG 480
KTKRFVDKID VDLDMREFYD EMTKISILKP FLH 514
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR003593--AAA+_ATPase
IPR016314--Cdc6/18
IPR015163--Cdc6_C_dom
IPR027417--P-loop_NTPase
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF13401--AAA_22
PF09079--Cdc6_C
Gene Ontology

GO:0005694--C:chromosome
GO:0031261--C:DNA replication preinitiation complex
GO:0005656--C:nuclear pre-replicative complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003682--F:chromatin binding
GO:0003688--F:DNA replication origin binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0051301--P:cell division
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0006267--P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0031938--P:regulation of chromatin silencing at telomere
GO:0030174--P:regulation of DNA-dependent DNA replication initiation