| Tag |
Content |
| dbPAF ID |
dbPAF-0004870 |
| Uniprot Accession |
P09081; BCD_DROME; Q5BI92; Q86BA9; Q86BP2; Q8INR7; Q8ST46; Q8STB1; Q8T9S9; Q8T9T0; Q8T9T1; Q95TN3; Q9UAM0; Q9VI47;
|
| Genbank Protein ID |
NP_476825.1; NP_731111.1; NP_731113.2; NP_788587.1; NP_788588.1;
|
| Genbank Nucleotide ID |
NM_057477.5; NM_169157.3; NM_169159.4; NM_176410.3; NM_176411.3;
|
| Protein Name |
Homeotic protein bicoid |
| Protein Synonyms/Alias |
PRD-4; |
| Gene Name |
bcd |
| Gene Synonyms/Alias |
CG1034; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.Functional Description
Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAQPPPDQNF YHHPLPHTHT HPHPHSHPHP HSHPHPHHQH PQLQLPPQFR NPFDLLFDER 60
TGAINYNYIR PYLPNQMPKP DVFPSEELPD SLVMRRPRRT RTTFTSSQIA ELEQHFLQGR 120
YLTAPRLADL SAKLALGTAQ VKIWFKNRRR RHKIQSDQHK DQSYEGMPLS PGMKQSDGDP 180
PSLQTLSLGG GATPNALTPS PTPSTPTAHM TEHYSESFNA YYNYNGGHNH AQANRHMHMQ 240
YPSGGGPGPG STNVNGGQFF QQQQVHNHQQ QLHHQGNHVP HQMQQQQQQA QQQQYHHFDF 300
QQKQASACRV LVKDEPEADY NFNSSYYMRS GMSGATASAS AVARGAASPG SEVYEPLTPK 360
NDESPSLCGI GIGGPCAIAV GETEAADDMD DGTSKKTTLQ ILEPLKGLDK SCDDGSSDDM 420
STGIRALAGT GNRGAAFAKF GKPSPPQGPQ PPLGMGGVAM GESNQYQCTM DTIMQAYNPH 480
RNAAGNSQFA YCFN
495Fasta Sequence
>P09081|bcd|Drosophila melanogaster(Fruit fly)
MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDFQQKQASACRVLVKDEPEADYNFNSSYYMRSGMSGATASASAVARGAASPGSEVYEPLTPKNDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQILEPLKGLDKSCDDGSSDDMSTGIRALAGTGNRGAAFAKFGKPSPPQGPQPPLGMGGVAMGESNQYQCTMDTIMQAYNPHRNAAGNSQFAYCFN
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF00046--Homeobox
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0016015--F:morphogen activity
GO:0003730--F:mRNA 3'-UTR binding
GO:0043565--F:sequence-specific DNA binding
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0030371--F:translation repressor activity
GO:0007355--P:anterior region determination
GO:0009948--P:anterior/posterior axis specification
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0008358--P:maternal determination of anterior/posterior axis, embryo
GO:0017148--P:negative regulation of translation
GO:0048477--P:oogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006417--P:regulation of translation
GO:0007367--P:segment polarity determination
GO:0006351--P:transcription, DNA-templated
|
