| Tag |
Content |
| dbPAF ID |
dbPAF-0004869 |
| Uniprot Accession |
P09077; SCR_DROME; Q23990; Q24508; Q9V3Q3;
|
| Genbank Protein ID |
NP_524248.2; NP_996165.1;
|
| Genbank Nucleotide ID |
NM_079524.4; NM_206443.2;
|
| Protein Name |
Homeotic protein Sex combs reduced |
| Protein Synonyms/Alias |
|
| Gene Name |
Scr |
| Gene Synonyms/Alias |
CG1030; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development.Functional Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG GVVPSGGTNG 60
GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA YGGQGNPDMV DYTQLQPQRL 120
LLQQQQQQQQ QQHAHAAAAV AAQQQQQLAQ QQHPQQQQQQ QQANISCKYA NDPVTPGGSG 180
GGGVSGSNNN NNSANSNNNN SQSLASPQDL STRDISPKLS PSSVVESVAR SLNKGVLGGS 240
LAAAAAAAGL NNNHSGSGVS GGPGNVNVPM HSPGGGDSDS ESDSGNEAGS SQNSGNGKKN 300
PPQIYPWMKR VHLGTSTVNA NGETKRQRTS YTRYQTLELE KEFHFNRYLT RRRRIEIAHA 360
LCLTERQIKI WFQNRRMKWK KEHKMASMNI VPYHMGPYGH PYHQFDIHPS QFAHLSA
418Fasta Sequence
>P09077|Scr|Drosophila melanogaster(Fruit fly)
MDPDCFAMSSYQFVNSLASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLSA
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR017995--Homeobox_antennapedia
IPR001827--Homeobox_Antennapedia_CS
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR020479--Homeobox_metazoa
IPR009057--Homeodomain-like
|
| PROSITE |
PS00032--ANTENNAPEDIA
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
|
| Pfam |
PF00046--Homeobox
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0007494--P:midgut development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007432--P:salivary gland boundary specification
GO:0007379--P:segment specification
GO:0045498--P:sex comb development
GO:0007548--P:sex differentiation
GO:0007381--P:specification of segmental identity, labial segment
|
