| Tag |
Content |
| dbPAF ID |
dbPAF-0004862 |
| Uniprot Accession |
P09052; VASA1_DROME; Q24582; Q8SXU8; Q9V3Q8;
|
| Genbank Protein ID |
NP_001260458.1; NP_723899.1;
|
| Genbank Nucleotide ID |
NM_001273529.2; NM_165103.3;
|
| Protein Name |
ATP-dependent RNA helicase vasa, isoform A |
| Protein Synonyms/Alias |
Antigen Mab46F11; |
| Gene Name |
vas |
| Gene Synonyms/Alias |
CG3506; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells.Functional Description
Involved in translational control mechanisms operating in early stages of oogenesis. Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts. Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation. Required for gus, Fsn and aub accumulation at the posterior pole of the embryo. Required for the localization of vas to the perinuclear region of nurse cells. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSDDWDDEPI VDTRGARGGD WSDDEDTAKS FSGEAEGDGV GGSGGEGGGY QGGNRDVFGR 60
IGGGRGGGAG GYRGGNRDGG GFHGGRREGE RDFRGGEGGF RGGQGGSRGG QGGSRGGQGG 120
FRGGEGGFRG RLYENEDGDE RRGRLDREER GGERRGRLDR EERGGERGER GDGGFARRRR 180
NEDDINNNNN IVEDVERKRE FYIPPEPSND AIEIFSSGIA SGIHFSKYNN IPVKVTGSDV 240
PQPIQHFTSA DLRDIIIDNV NKSGYKIPTP IQKCSIPVIS SGRDLMACAQ TGSGKTAAFL 300
LPILSKLLED PHELELGRPQ VVIVSPTREL AIQIFNEARK FAFESYLKIG IVYGGTSFRH 360
QNECITRGCH VVIATPGRLL DFVDRTFITF EDTRFVVLDE ADRMLDMGFS EDMRRIMTHV 420
TMRPEHQTLM FSATFPEEIQ RMAGEFLKNY VFVAIGIVGG ACSDVKQTIY EVNKYAKRSK 480
LIEILSEQAD GTIVFVETKR GADFLASFLS EKEFPTTSIH GDRLQSQREQ ALRDFKNGSM 540
KVLIATSVAS RGLDIKNIKH VINYDMPSKI DDYVHRIGRT GRVGNNGRAT SFFDPEKDRA 600
IAADLVKILE GSGQTVPDFL RTCGAGGDGG YSNQNFGGVD VRGRGNYVGD ATNVEEEEQW 660
D
662Fasta Sequence
>P09052|vas|Drosophila melanogaster(Fruit fly)
MSDDWDDEPIVDTRGARGGDWSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQGGNRDVFGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGFRGRLYENEDGDERRGRLDREERGGERRGRLDREERGGERGERGDGGFARRRRNEDDINNNNNIVEDVERKREFYIPPEPSNDAIEIFSSGIASGIHFSKYNNIPVKVTGSDVPQPIQHFTSADLRDIIIDNVNKSGYKIPTPIQKCSIPVISSGRDLMACAQTGSGKTAAFLLPILSKLLEDPHELELGRPQVVIVSPTRELAIQIFNEARKFAFESYLKIGIVYGGTSFRHQNECITRGCHVVIATPGRLLDFVDRTFITFEDTRFVVLDEADRMLDMGFSEDMRRIMTHVTMRPEHQTLMFSATFPEEIQRMAGEFLKNYVFVAIGIVGGACSDVKQTIYEVNKYAKRSKLIEILSEQADGTIVFVETKRGADFLASFLSEKEFPTTSIHGDRLQSQREQALRDFKNGSMKVLIATSVASRGLDIKNIKHVINYDMPSKIDDYVHRIGRTGRVGNNGRATSFFDPEKDRAIAADLVKILEGSGQTVPDFLRTCGAGGDGGYSNQNFGGVDVRGRGNYVGDATNVEEEEQWD
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0347--Helicase
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0547--Nucleotide-binding
KW-0896--Oogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0832--Ubl conjugation
|
| Interpro |
IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000629--RNA-helicase_DEAD-box_CS
IPR014014--RNA_helicase_DEAD_Q_motif
|
| PROSITE |
PS00039--DEAD_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51195--Q_MOTIF
|
| Pfam |
PF00270--DEAD
PF00271--Helicase_C
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0043186--C:P granule
GO:0048471--C:perinuclear region of cytoplasm
GO:0045495--C:pole plasm
GO:0045170--C:spectrosome
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003730--F:mRNA 3'-UTR binding
GO:0003723--F:RNA binding
GO:0003724--F:RNA helicase activity
GO:0046843--P:dorsal appendage formation
GO:0048134--P:germ-line cyst formation
GO:0007293--P:germarium-derived egg chamber formation
GO:0007294--P:germarium-derived oocyte fate determination
GO:0008298--P:intracellular mRNA localization
GO:0030717--P:karyosome formation
GO:0007076--P:mitotic chromosome condensation
GO:0006378--P:mRNA polyadenylation
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0048477--P:oogenesis
GO:0007315--P:pole plasm assembly
GO:0007316--P:pole plasm RNA localization
GO:0046012--P:positive regulation of oskar mRNA translation
GO:0045727--P:positive regulation of translation
GO:0008104--P:protein localization
GO:0046011--P:regulation of oskar mRNA translation
GO:0006417--P:regulation of translation
|
