| Tag |
Content |
| dbPAF ID |
dbPAF-0004843 |
| Uniprot Accession |
P08985; H2AV_DROME; A0ANX7; A0ANX8; A0ANY0; A0ANY3; C0MJB2; C0MJB9; Q26252; Q540X2; Q9VBB1;
|
| Genbank Protein ID |
NP_001262997.1; NP_524519.1;
|
| Genbank Nucleotide ID |
NM_001276068.1; NM_079795.3;
|
| Protein Name |
Histone H2A.v |
| Protein Synonyms/Alias |
H2A.F/Z;H2A.Z; |
| Gene Name |
His2Av |
| Gene Synonyms/Alias |
H2AvD;His2AvD;CG5499; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.Functional Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 138 | RKGNVILSQAY---- | dbPTM 3.0;Phospho.ELM 9.0;UniProt | 12202754; 16381945; 23193290 |
|
Sequence
(Fasta) | MAGGKAGKDS GKAKAKAVSR SARAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE 60
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 120
KKEETVQDPQ RKGNVILSQA Y
142Fasta Sequence
>P08985|His2Av|Drosophila melanogaster(Fruit fly)
MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKEETVQDPQRKGNVILSQAY
|
| Keyword |
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0544--Nucleosome core
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
|
| Interpro |
IPR009072--Histone-fold
IPR002119--Histone_H2A
IPR007125--Histone_H2A/H2B/H3
IPR032454--Histone_H2A_C
IPR032458--Histone_H2A_CS
|
| PROSITE |
PS00046--HISTONE_H2A
|
| Pfam |
PF00125--Histone
PF16211--Histone_H2A_C
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005811--C:lipid particle
GO:0000790--C:nuclear chromatin
GO:0000786--C:nucleosome
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0005701--C:polytene chromosome chromocenter
GO:0003677--F:DNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006325--P:chromatin organization
GO:0006342--P:chromatin silencing
GO:0006281--P:DNA repair
GO:0036098--P:male germ-line stem cell population maintenance
GO:0007275--P:multicellular organismal development
GO:0071168--P:protein localization to chromatin
GO:0035019--P:somatic stem cell population maintenance
|
