| Tag |
Content |
| dbPAF ID |
dbPAF-0004838 |
| Uniprot Accession |
P08953; TOLL_DROME; A4V3G7; A8WHK7; Q8MRF3; Q9VBB8;
|
| Genbank Protein ID |
NP_524518.1; NP_733166.1;
|
| Genbank Nucleotide ID |
NM_079794.3; NM_170287.3;
|
| Protein Name |
Protein toll |
| Protein Synonyms/Alias |
|
| Gene Name |
Tl |
| Gene Synonyms/Alias |
CG5490; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Receptor for the cleaved activated form of spz, spaetzle C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:12872120, PubMed:8808632). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:3931919). Promotes heterophilic cellular adhesion (PubMed:2124970).Functional Description
Receptor for the cleaved activated form of spz, spaetzle C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:12872120, PubMed:8808632). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:3931919). Promotes heterophilic cellular adhesion (PubMed:2124970). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSRLKAASEL ALLVIILQLL QWPGSEASFG RDACSEMSID GLCQCAPIMS EYEIICPANA 60
ENPTFRLTIQ PKDYVQIMCN LTDTTDYQQL PKKLRIGEVD RVQMRRCMLP GHTPIASILD 120
YLGIVSPTTL IFESDNLGMN ITRQHLDRLH GLKRFRFTTR RLTHIPANLL TDMRNLSHLE 180
LRANIEEMPS HLFDDLENLE SIEFGSNKLR QMPRGIFGKM PKLKQLNLWS NQLHNLTKHD 240
FEGATSVLGI DIHDNGIEQL PHDVFAHLTN VTDINLSANL FRSLPQGLFD HNKHLNEVRL 300
MNNRVPLATL PSRLFANQPE LQILRLRAEL QSLPGDLFEH STQITNISLG DNLLKTLPAT 360
LLEHQVNLLS LDLSNNRLTH LPDSLFAHTT NLTDLRLEDN LLTGISGDIF SNLGNLVTLV 420
MSRNRLRTID SRAFVSTNGL RHLHLDHNDI DLQQPLLDIM LQTQINSPFG YMHGLLTLNL 480
RNNSIIFVYN DWKNTMLQLR ELDLSYNNIS SLGYEDLAFL SQNRLHVNMT HNKIRRIALP 540
EDVHLGEGYN NNLVHVDLND NPLVCDCTIL WFIQLVRGVH KPQYSRQFKL RTDRLVCSQP 600
NVLEGTPVRQ IEPQTLICPL DFSDDPRERK CPRGCNCHVR TYDKALVINC HSGNLTHVPR 660
LPNLHKNMQL MELHLENNTL LRLPSANTPG YESVTSLHLA GNNLTSIDVD QLPTNLTHLD 720
ISWNHLQMLN ATVLGFLNRT MKWRSVKLSG NPWMCDCTAK PLLLFTQDNF ERIGDRNEMM 780
CVNAEMPTRM VELSTNDICP AEKGVFIALA VVIALTGLLA GFTAALYYKF QTEIKIWLYA 840
HNLLLWFVTE EDLDKDKKFD AFISYSHKDQ SFIEDYLVPQ LEHGPQKFQL CVHERDWLVG 900
GHIPENIMRS VADSRRTIIV LSQNFIKSEW ARLEFRAAHR SALNEGRSRI IVIIYSDIGD 960
VEKLDEELKA YLKMNTYLKW GDPWFWDKLR FALPHRRPVG NIGNGALIKT ALKGSTDDKL 1020
ELIKPSPVTP PLTTPPAEAT KNPLVAQLNG VTPHQAIMIA NGKNGLTNLY TPNGKSHGNG 1080
HINGAFIINT NAKQSDV
1098Fasta Sequence
>P08953|Tl|Drosophila melanogaster(Fruit fly)
MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV
|
| Keyword |
KW-0002--3D-structure
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR000483--Cys-rich_flank_reg_C
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR026906--LRR_5
IPR000372--LRRNT
IPR000157--TIR_dom
IPR027202--Toll
|
| PROSITE |
PS51450--LRR
PS50104--TIR
|
| Pfam |
PF00560--LRR_1
PF13306--LRR_5
PF13855--LRR_8
PF01462--LRRNT
PF01582--TIR
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0032154--C:cleavage furrow
GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0009897--C:external side of plasma membrane
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0019955--F:cytokine binding
GO:0042802--F:identical protein binding
GO:0070976--F:TIR domain binding
GO:0004888--F:transmembrane signaling receptor activity
GO:0019732--P:antifungal humoral response
GO:0019730--P:antimicrobial humoral response
GO:0007155--P:cell adhesion
GO:0006952--P:defense response
GO:0050832--P:defense response to fungus
GO:0050830--P:defense response to Gram-positive bacterium
GO:0002229--P:defense response to oomycetes
GO:0009950--P:dorsal/ventral axis specification
GO:0009880--P:embryonic pattern specification
GO:0007507--P:heart development
GO:0035172--P:hemocyte proliferation
GO:0030097--P:hemopoiesis
GO:0006955--P:immune response
GO:0045087--P:innate immune response
GO:0000281--P:mitotic cytokinesis
GO:0006963--P:positive regulation of antibacterial peptide biosynthetic process
GO:0006967--P:positive regulation of antifungal peptide biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1902875--P:regulation of embryonic pattern specification
GO:0045610--P:regulation of hemocyte differentiation
GO:0035007--P:regulation of melanization defense response
GO:0009617--P:response to bacterium
GO:0009620--P:response to fungus
GO:0007416--P:synapse assembly
GO:0016201--P:synaptic target inhibition
GO:0008063--P:Toll signaling pathway
GO:0007352--P:zygotic specification of dorsal/ventral axis
|
