dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004800
Uniprot Accession P08678; CYAA_YEAST; D6VWH0;
Genbank Protein ID NP_012529.3;
Genbank Nucleotide ID NM_001181439.3;
Protein Name Adenylate cyclase
Protein Synonyms/Alias ATP pyrophosphate-lyase;Adenylyl cyclase;
Gene Name CYR1
Gene Synonyms/Alias CDC35;HSR1;SRA4;YJL005W;J1401;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Phosphorylation Sites
 dbPAF PTMs: 99 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9SSKPDTGSEISGPQRcurated26040289
12PDTGSEISGPQRQEEcurated24961812
27QEQQIEQSSPTEANDPhosphoGRID 2.0;curated21126336; 19823750
28EQQIEQSSPTEANDRPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19779198; 19060867; 26040289; 22369663; 22817900;
30QIEQSSPTEANDRSIcurated22817900
36PTEANDRSIHDEVPKcurated25315811
56EQNSGHKSRRNSAYScurated24961812
60GHKSRRNSAYSYYSPPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040406; 22369663; 22817900; 24961812;
62KSRRNSAYSYYSPRSPhosphoGRID 2.0;curated19779198; 26040289; 22817900; 24961812
63SRRNSAYSYYSPRSLPhosphoGRID 2.0;curated19779198; 26040289; 24961812
65RNSAYSYYSPRSLSMcurated25315811
66NSAYSYYSPRSLSMTcurated22369663; 22817900; 19547744
69YSYYSPRSLSMTKSRPhosphoPep 2.019060867
71YYSPRSLSMTKSRESPhosphoPep 2.0;curated19060867; 22817900; 24961812; 19547744
73SPRSLSMTKSRESITPhosphoPep 2.019060867
75RSLSMTKSRESITPNcurated26040289; 20377248
78SMTKSRESITPNGMDPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 26040289; 22369663; 20377248
88PNGMDDVSISNVEHPcurated26040289
90GMDDVSISNVEHPRPcurated26040289
112GPYLLKKTLSSLSMTcurated25315811
Sequence
(Fasta)		MSSKPDTGSE ISGPQRQEEQ EQQIEQSSPT EANDRSIHDE VPKVKKRHEQ NSGHKSRRNS 60
AYSYYSPRSL SMTKSRESIT PNGMDDVSIS NVEHPRPTEP KIKRGPYLLK KTLSSLSMTS 120
ANSTHDDNKD HGYALNSSKT HNYTSTHNHH DGHHDHHHVQ FFPNRKPSLA ETLFKRFSGS 180
NSHDGNKSGK ESKVANLSLS TVNPAPANRK PSKDSTLSNH LADNVPSTLR RKVSSLVRGS 240
SVHDINNGIA DKQIRPKAVA QSENTLHSSD VPNSKRSHRK SFLLGSTSSS SSRRGSNVSS 300
MTNSDSASMA TSGSHVLQHN VSNVSPTTKS KDSVNSESAD HTNNKSEKVT PEYNENIPEN 360
SNSDNKREAT TPTIETPISC KPSLFRLDTN LEDVTDITKT VPPTAVNSTL NSTHGTETAS 420
PKTVIMPEGP RKSVSMADLS VAAAAPNGEF TSTSNDRSQW VAPQSWDVET KRKKTKPKGR 480
SKSRRSSIDA DELDPMSPGP PSKKDSRHHH DRKDNESMVT AGDSNSSFVD ICKENVPNDS 540
KTALDTKSVN RLKSNLAMSP PSIRYAPSNL DGDYDTSSTS SSLPSSSISS EDTSSCSDSS 600
SYTNAYMEAN REQDNKTPIL NKTKSYTKKF TSSSVNMNSP DGAQSSGLLL QDEKDDEVEC 660
QLEHYYKDFS DLDPKRHYAI RIFNTDDTFT TLSCTPATTV EEIIPALKRK FNITAQGNFQ 720
ISLKVGKLSK ILRPTSKPIL IERKLLLLNG YRKSDPLHIM GIEDLSFVFK FLFHPVTPSH 780
FTPEQEQRIM RSEFVHVDLR NMDLTTPPII FYQHTSEIES LDVSNNANIF LPLEFIESSI 840
KLLSLRMVNI RASKFPSNIT KAYKLVSLEL QRNFIRKVPN SIMKLSNLTI LNLQCNELES 900
LPAGFVELKN LQLLDLSSNK FMHYPEVINY CTNLLQIDLS YNKIQSLPQS TKYLVKLAKM 960
NLSHNKLNFI GDLSEMTDLR TLNLRYNRIS SIKTNASNLQ NLFLTDNRIS NFEDTLPKLR 1020
ALEIQENPIT SISFKDFYPK NMTSLTLNKA QLSSIPGELL TKLSFLEKLE LNQNNLTRLP 1080
QEISKLTKLV FLSVARNKLE YIPPELSQLK SLRTLDLHSN NIRDFVDGME NLELTSLNIS 1140
SNAFGNSSLE NSFYHNMSYG SKLSKSLMFF IAADNQFDDA MWPLFNCFVN LKVLNLSYNN 1200
FSDVSHMKLE SITELYLSGN KLTTLSGDTV LKWSSLKTLM LNSNQMLSLP AELSNLSQLS 1260
VFDVGANQLK YNISNYHYDW NWRNNKELKY LNFSGNRRFE IKSFISHDID ADLSDLTVLP 1320
QLKVLGLMDV TLNTTKVPDE NVNFRLRTTA SIINGMRYGV ADTLGQRDYV SSRDVTFERF 1380
RGNDDECLLC LHDSKNQNAD YGHNISRIVR DIYDKILIRQ LERYGDETDD NIKTALRFSF 1440
LQLNKEINGM LNSVDNGADV ANLSYADLLS GACSTVIYIR GKKLFAANLG DCMAILSKNN 1500
GDYQTLTKQH LPTKREEYER IRISGGYVNN GKLDGVVDVS RAVGFFDLLP HIHASPDISV 1560
VTLTKADEML IVATHKLWEY MDVDTVCDIA RENSTDPLRA AAELKDHAMA YGCTENITIL 1620
CLALYENIQQ QNRFTLNKNS LMTRRSTFED TTLRRLQPEI SPPTGNLAMV FTDIKSSTFL 1680
WELFPNAMRT AIKTHNDIMR RQLRIYGGYE VKTEGDAFMV AFPTPTSGLT WCLSVQLKLL 1740
DAQWPEEITS VQDGCQVTDR NGNIIYQGLS VRMGIHWGCP VPELDLVTQR MDYLGPMVNK 1800
AARVQGVADG GQIAMSSDFY SEFNKIMKYH ERVVKGKESL KEVYGEEIIG EVLEREIAML 1860
ESIGWAFFDF GEHKLKGLET KELVTIAYPK ILASRHEFAS EDEQSKLINE TMLFRLRVIS 1920
NRLESIMSAL SGGFIELDSR TEGSYIKFNP KVENGIMQSI SEKDALLFFD HVITRIESSV 1980
ALLHLRQQRC SGLEICRNDK TSARSNIFNV VDELLQMVKN AKDLST 2027
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0115--cAMP biosynthesis
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0456--Lyase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR001054--A/G_cyclase
IPR013716--Adenylate_cyclase_G-a-bd
IPR001611--Leu-rich_rpt
IPR029787--Nucleotide_cyclase
IPR001932--PPM-type_phosphatase_dom
IPR000159--RA_dom
PROSITE

PS50125--GUANYLATE_CYCLASE_2
PS51450--LRR
PS51746--PPM_2
PS50200--RA
Pfam

PF08509--Ad_cyc_g-alpha
PF00211--Guanylate_cyc
PF13855--LRR_8
PF00481--PP2C
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0004016--F:adenylate cyclase activity
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007265--P:Ras protein signal transduction