dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004758
Uniprot Accession P08466; NUC1_YEAST; D6VVY6;
Genbank Protein ID NP_012327.1;
Genbank Nucleotide ID NM_001181641.1;
Protein Name Mitochondrial nuclease
Protein Synonyms/Alias
Gene Name NUC1
Gene Synonyms/Alias YJL208C;HRE329;J0310;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 This enzyme has both RNase and DNase activity.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
195YKSVRIVTGPLYLPKcurated22817900
199RIVTGPLYLPKKDPIcurated22817900
Sequence
(Fasta)		MCSRILLSGL VGLGAGTGLT YLLLNKHSPT QIIETPYPPT QKPNSNIQSH SFNVDPSGFF 60
KYGFPGPIHD LQNREEFISC YNRQTQNPYW VLEHITPESL AARNADRKNS FFKEDEVIPE 120
KFRGKLRDYF RSGYDRGHQA PAADAKFSQQ AMDDTFYLSN MCPQVGEGFN RDYWAHLEYF 180
CRGLTKKYKS VRIVTGPLYL PKKDPIDNKF RVNYEVIGNP PSIAVPTHFF KLIVAEAPTA 240
NPAREDIAVA AFVLPNEPIS NETKLTDFEV PIDALERSTG LELLQKVPPS KKKALCKEVN 300
CQIVVRDFSN AAIKQSKDVK LLPPPKKRN
Keyword

KW-0181--Complete proteome
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0540--Nuclease
KW-1185--Reference proteome
Interpro

IPR018524--DNA/RNA_endonuclease_AS
IPR001604--DNA/RNA_non-sp_Endonuclease
IPR020821--Extracellular_endonuc_su_A
PROSITE

PS01070--NUCLEASE_NON_SPEC
Pfam

PF01223--Endonuclease_NS
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004520--F:endodeoxyribonuclease activity
GO:0004529--F:exodeoxyribonuclease activity
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0004540--F:ribonuclease activity
GO:0006309--P:apoptotic DNA fragmentation
GO:0006915--P:apoptotic process
GO:0006308--P:DNA catabolic process
GO:0006310--P:DNA recombination
GO:0006401--P:RNA catabolic process
GO:0090501--P:RNA phosphodiester bond hydrolysis