dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004738
Uniprot Accession P08266; RPB2_DROME; Q04155; Q95027; Q9VFM7;
Genbank Protein ID NP_001287323.1; NP_476706.1;
Genbank Nucleotide ID NM_001300394.1; NM_057358.4;
Protein Name DNA-directed RNA polymerase II subunit RPB2
Protein Synonyms/Alias
Gene Name RpII140
Gene Synonyms/Alias CG3180;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
587DPEQLMATLRKLRRQcurated22817900
Sequence
(Fasta)
MMYDNEEELY EEENAEEISH ELWQEACWIV INAYFDEKGL VRQQLDSFDE FIQMSVQRIV 60
EDSPAIELQA EAQHTSGEVE TPPRFSLKFE QIYLSKPTHW EKDGSPSPMM PNEARLRNLT 120
YSAPLYVDIT KTKNVEGLDP VETQHQKTFI GKIPIMLRST YCLLSQLTDR DLTELNECPL 180
DPGGYFIING SEKVLIAQEK MATNTVYVFS MKDGKYAFKT EIRSCLEHSS RPTSTLWVNM 240
MARGSQNIKK SAIGQRIIAI LPYIKQEIPI MIVFRALGFV ADRDILEHII YDFDDPEMME 300
MVKPSLDEAF VVQEQNVALN FIGARGARPG VTKDKRIKYA KEILQKEMLP HVGVSDFCET 360
KKAYFLGYMV HRLLLASLGR RELDDRDHYG NKRLDLAGPL LAFLFRGLFK NLMKEVRMYT 420
QKFIDRGKDF NLELAIKTNI ITDGLRYSLA TGNWGDQKKA HQARAGVSQV LNRLTFASTL 480
SHLRRVNSPI GRDGKLAKPR QLHNTLWGML CPAETPEGAA VGLVKNLALM AYISVGSQPS 540
PILEFLEEWS MENLEEIAPS AIADATKIFV NGCWVGIHRD PEQLMATLRK LRRQMDIIVS 600
EVSMIRDIRD REIRIYTDAG RICRPLLIVE NGSLLLKKTH VEMLKERDYN NYSWQVLVAS 660
GVVEYIDTLE EETVMIAMSP YDLKQDKDYA YCTTYTHCEI HPAMILGVCA SIIPFPDHNQ 720
SPRNTYQSAM GKQAMGVYIT NFHVRMDTLA HVLYYPMKPL VTTRSMEYLR FRELPAGINS 780
IVAILCYTGY NQEDSVILNA SAVERGFFRS VFYRSYKDSE NKRVGDQEEN FEKPHRGTCQ 840
GMRNAHYDKL DDDGIIAPGI RVSGDDVVIG KTITLPENDD ELDSNTKRFS KRDASTFLRN 900
SETGIVDQVM LTLNSEGYKF CKIRVRSVRI PQIGDKFASR HGQKGTCGIQ YRQEDMAFTC 960
EGLAPDIIIN PHAIPSRMTI GHLIECLQGK LGSNKGEIGD ATPFNDAVNV QKISTFLQEY 1020
GYHLRGNEVM YNGHTGRKIN AQVFLGPTYY QRLKHMVDDK IHSRARGPVQ ILVRQPMEGR 1080
ARDGGLRFGE MERDCQISHG AAQFLRERLF EVSDPYRVHI CNFCGLIAIA NLRNNTFECK 1140
GCKNKTQISQ VRLPYAAKLL FQELMSMNIA PRLMVT 1177
Keyword

KW-0181--Complete proteome
KW-0240--DNA-directed RNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015712--DNA-dir_RNA_pol_su2
IPR007120--DNA-dir_RNA_pol_su2_6
IPR007121--RNA_pol_bsu_CS
IPR007644--RNA_pol_bsu_protrusion
IPR007642--RNA_pol_Rpb2_2
IPR007645--RNA_pol_Rpb2_3
IPR007646--RNA_pol_Rpb2_4
IPR007647--RNA_pol_Rpb2_5
IPR007641--RNA_pol_Rpb2_7
IPR014724--RNA_pol_RPB2_OB-fold

PROSITE

PS01166--RNA_POL_BETA

Pfam

PF04563--RNA_pol_Rpb2_1
PF04561--RNA_pol_Rpb2_2
PF04565--RNA_pol_Rpb2_3
PF04566--RNA_pol_Rpb2_4
PF04567--RNA_pol_Rpb2_5
PF00562--RNA_pol_Rpb2_6
PF04560--RNA_pol_Rpb2_7

Gene Ontology

GO:0005665--C:DNA-directed RNA polymerase II, core complex
GO:0003677--F:DNA binding
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0046872--F:metal ion binding
GO:0032549--F:ribonucleoside binding
GO:0006366--P:transcription from RNA polymerase II promoter