dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004713
Uniprot Accession P08153; SWI5_YEAST; D6VSC9; E9P945;
Genbank Protein ID NP_010430.1;
Genbank Nucleotide ID NM_001180453.1;
Protein Name Transcriptional factor SWI5
Protein Synonyms/Alias
Gene Name SWI5
Gene Synonyms/Alias YDR146C;YD8358.03C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.
Phosphorylation Sites
 dbPAF PTMs: 38 (View all)
PositionPeptidesSourceReferences ( PMIDs )
218LQATLENSDGPQFLScurated22817900
225SDGPQFLSPKRKISPPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19823750; 19779198; 19795423; 19060867; 26040289; 22369663;
246DVYANSLSPMISPPMcurated22817900
250NSLSPMISPPMSNTSPhosphoGRID 2.0;curated19779198; 22817900
261SNTSFTGSPSRRNNRPhosphoGRID 2.019779198
278YCLQRKNSSGTVGPLdbPTM 3.0;PhosphoGRID 2.0;UniProt;curated17563356; 16381945; 23193290; 19779198; 22817900
279CLQRKNSSGTVGPLCPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 22817900
281QRKNSSGTVGPLCFQPhosphoPep 2.0;curated19060867; 22817900
297LNEGFNDSLISPKKIPhosphoGRID 2.019779198
300GFNDSLISPKKIRSNPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19823750; 19779198; 19795423; 19060867; 22369663; 22817900;
316NENLSSKTKFITPFTcurated22817900
323TKFITPFTPKSRVSScurated24961812
329FTPKSRVSSATSNSAPhosphoPep 2.019060867
339TSNSANITPNNLRLDPhosphoPep 2.0;UniProt;curated19060867; 19779198; 22817900; 24961812
376LLGKPGPSPTKSVSLPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated19823750; 19795423; 19060867; 19779198; 26040289; 22817900;
378GKPGPSPTKSVSLKScurated22369663; 20377248
380PGPSPTKSVSLKSASPhosphoPep 2.019060867
397IMPTIPGSVNNTPSVPhosphoGRID 2.0;curated19684113; 25704821; 22817900; 24961812
401IPGSVNNTPSVNKVSPhosphoGRID 2.0;curated19684113; 22817900; 24961812
403GSVNNTPSVNKVSLScurated25704821
Sequence
(Fasta)		MDTSNSWFDA SKVQSLNFDL QTNSYYSNAR GSDPSSYAIE GEYKTLATDD LGNILNLNYG 60
ETNEVIMNEI NDLNLPLGPL SDEKSVKVST FSELIGNDWQ SMNFDLENNS REVTLNATSL 120
LNENRLNQDS GMTVYQKTMS DKPHDEKKIS MADNLLSTIN KSEINKGFDR NLGELLLQQQ 180
QELREQLRAQ QEANKKLELE LKQTQYKQQQ LQATLENSDG PQFLSPKRKI SPASENVEDV 240
YANSLSPMIS PPMSNTSFTG SPSRRNNRQK YCLQRKNSSG TVGPLCFQEL NEGFNDSLIS 300
PKKIRSNPNE NLSSKTKFIT PFTPKSRVSS ATSNSANITP NNLRLDFKIN VEDQESEYSE 360
KPLGLGIELL GKPGPSPTKS VSLKSASVDI MPTIPGSVNN TPSVNKVSLS SSYIDQYTPR 420
GKQLHFSSIS ENALGINAAT PHLKPPSQQA RHREGVFNDL DPNVLTKNTD NEGDDNEENE 480
PESRFVISET PSPVLKSQSK YEGRSPQFGT HIKEINTYTT NSPSKITRKL TTLPRGSIDK 540
YVKEMPDKTF ECLFPGCTKT FKRRYNIRSH IQTHLEDRPY SCDHPGCDKA FVRNHDLIRH 600
KKSHQEKAYA CPCGKKFNRE DALVVHRSRM ICSGGKKYEN VVIKRSPRKR GRPRKDGTSS 660
VSSSPIKENI NKDHNGQLMF KLEDQLRRER SYDGNGTGIM VSPMKTNQR
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017956--AT_hook_DNA-bd_motif
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0036033--F:mediator complex binding
GO:0046872--F:metal ion binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001133--F:RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
GO:0031496--P:positive regulation of mating type switching
GO:0007074--P:positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0006351--P:transcription, DNA-templated