dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004702
Uniprot Accession P08111; L2GL_DROME; A4UZW0; D0IQ91; D0IQJ0; Q0E8V5; Q24377; Q8IPV4; Q8IPV5; Q9VPI1;
Genbank Protein ID NP_001245801.1; NP_001245802.1; NP_001245803.1; NP_001245804.1; NP_523439.2; NP_722583.1; NP_722584.1; NP_722585.1; NP_722586.1; NP_722587.1;
Genbank Nucleotide ID NM_001258872.2; NM_001258873.2; NM_001258874.2; NM_001258875.2; NM_078715.4; NM_164348.3; NM_164349.3; NM_164350.3; NM_164351.3; NM_164352.3;
Protein Name Lethal(2) giant larvae protein
Protein Synonyms/Alias
Gene Name l(2)gl
Gene Synonyms/Alias CG2671;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
473SSIFGSESDFRDDAAdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
484DDAAADMSAEQVDEGdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
679RSTRTNQSNQVPTTLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;UniProt;curated18327897; 16381945; 23193290; 21081558; 22817900
770PHMPRRISAQLAKEIPHOSIDA;curated21081558; 22817900
808LNAGENGSPPHRVLIdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
869LQSMHGCSPTKSTRSdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
873HGCSPTKSTRSHGDGdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
876SPTKSTRSHGDGEADdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
887GEADPNISGSLAVSRdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
889ADPNISGSLAVSRGDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
893ISGSLAVSRGDVYNEdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
984EPLENEESVLEENDAPHOSIDA;curated21081558; 22817900
1013TYEIKNPSGISICTRdbPTM 3.0;Phospho.ELM 9.0;UniProt;curated18327897; 16381945; 23193290; 22817900
1086EETIGRLSVLSTQTNPHOSIDA;curated21081558; 22817900
1089IGRLSVLSTQTNKASPHOSIDA21081558
1121DLESKRNTTETSTSSPHOSIDA;curated21081558; 22817900
1139KSIITNISHEKTNGDPHOSIDA;curated21081558; 22817900
Sequence
(Fasta)		MLKFIRGKGQ QPSADRHRLQ KDLFAYRKTA QHGFPHKPSA LAYDPVLKLM AIGTQTGALK 60
VFGQPGVELY GQHTLLNNSA SELNVQLLEW VYGTGRILSL TAANQLILWE PVGATLLPIK 120
TLPFDGKLKK VSSLCCSLSK DLLWIGTEGG NIYQLDLHTF TIKEPVIYHD VVLEQVPPAY 180
KLNPGAIESI RQLPNSPSKL LVAYNRGLCV LWDFESASVQ RAYIAPGHGQ SVGLTVNFEG 240
SEFTWYHADG SYATWSIDNP EPPSNVNYVP YGPDPCKSIN RLYKGKRRSN DVIVFSGGMP 300
RSAYGDHNCV SVHASDGHKV CLDFTSKVID FFVTFENNRD VAEVLVVLLE EELCAYDLTD 360
PNICAIKAPY LHSVHASAVT CNYLASEVVQ SVYESILRAG DEQDIDYSNI SWPITGGTLP 420
DNLEESVEED ATKLYEILLT GHEDGSVKFW DCTGVLLKPI YNFKTSSIFG SESDFRDDAA 480
ADMSAEQVDE GEPPFRKSGL FDPYSDDPRL AVKKIAFCPK TGQLIVGGTA GQIVIADFID 540
LPEKVSLKYI SMNLVSDRDG FVWKGHDQLN VRSNLLDGEA IPTTERGVNI SGVLQVLPPA 600
SITCMALEAS WGLVSGGTAH GLVLFDFKNF VPVFHRCTLN PNDLTGAGEQ LSRRKSFKKS 660
LRESFRKLRK GRSTRTNQSN QVPTTLEARP VERQIEARCA DDGLGSMVRC LLFAKTYVTN 720
VNITSPTLWS ATNASTVSVF LLHLPPAQTA ATAVPSASGN APPHMPRRIS AQLAKEIQLK 780
HRAPVVGISI FDQAGSPVDQ LNAGENGSPP HRVLIASEEQ FKVFSLPQLK PINKYKLTAN 840
EGARIRRIHF GSFSCRISPE TLQSMHGCSP TKSTRSHGDG EADPNISGSL AVSRGDVYNE 900
TALICLTNMG DIMVLSVPEL KRQLNAAAVR REDINGVSSL CFTNSGEALY MMSSSELQRI 960
ALATSRVVQP TGVVPVEPLE NEESVLEEND AENNKETYAC DEVVNTYEIK NPSGISICTR 1020
PAEENVGRNS VQQVNGVNIS NSPNQANETI SSSIGDITVD SVRDHLNMTT TTLCSINTEE 1080
TIGRLSVLST QTNKASTTVN MSEIPNINIS NLEDLESKRN TTETSTSSVV IKSIITNISH 1140
EKTNGDNKIG TPKTAPEESQ F 1162
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0268--Exocytosis
KW-0272--Extracellular matrix
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0043--Tumor suppressor
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013905--Lgl_C_dom
IPR013577--LLGL2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
Pfam

PF08596--Lgl_C
PF08366--LLGL
Gene Ontology

GO:0016327--C:apicolateral plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005938--C:cell cortex
GO:0030864--C:cortical actin cytoskeleton
GO:0030863--C:cortical cytoskeleton
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005578--C:proteinaceous extracellular matrix
GO:0005918--C:septate junction
GO:0005920--C:smooth septate junction
GO:0008021--C:synaptic vesicle
GO:0005096--F:GTPase activator activity
GO:0017022--F:myosin binding
GO:0045159--F:myosin II binding
GO:0004860--F:protein kinase inhibitor activity
GO:0017137--F:Rab GTPase binding
GO:0000149--F:SNARE binding
GO:0019905--F:syntaxin binding
GO:0030036--P:actin cytoskeleton organization
GO:0045176--P:apical protein localization
GO:0055059--P:asymmetric neuroblast division
GO:0008105--P:asymmetric protein localization
GO:0045167--P:asymmetric protein localization involved in cell fate determination
GO:0045175--P:basal protein localization
GO:0035212--P:cell competition in a multicellular organism
GO:0008283--P:cell proliferation
GO:0035293--P:chitin-based larval cuticle pattern formation
GO:0030866--P:cortical actin cytoskeleton organization
GO:0007391--P:dorsal closure
GO:0035072--P:ecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0048730--P:epidermis morphogenesis
GO:0060429--P:epithelium development
GO:0090163--P:establishment of epithelial cell planar polarity
GO:0000132--P:establishment of mitotic spindle orientation
GO:0045200--P:establishment of neuroblast polarity
GO:0045184--P:establishment of protein localization
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0045196--P:establishment or maintenance of neuroblast polarity
GO:0016332--P:establishment or maintenance of polarity of embryonic epithelium
GO:0016334--P:establishment or maintenance of polarity of follicular epithelium
GO:0016336--P:establishment or maintenance of polarity of larval imaginal disc epithelium
GO:0007293--P:germarium-derived egg chamber formation
GO:0051668--P:localization within membrane
GO:0001738--P:morphogenesis of a polarized epithelium
GO:0002009--P:morphogenesis of an epithelium
GO:0016333--P:morphogenesis of follicular epithelium
GO:0016335--P:morphogenesis of larval imaginal disc epithelium
GO:0008285--P:negative regulation of cell proliferation
GO:1904030--P:negative regulation of cyclin-dependent protein kinase activity
GO:0007406--P:negative regulation of neuroblast proliferation
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0006469--P:negative regulation of protein kinase activity
GO:0007399--P:nervous system development
GO:0007269--P:neurotransmitter secretion
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0016325--P:oocyte microtubule cytoskeleton organization
GO:0043547--P:positive regulation of GTPase activity
GO:0008104--P:protein localization
GO:0072697--P:protein localization to cell cortex
GO:0051726--P:regulation of cell cycle
GO:0008360--P:regulation of cell shape
GO:0032878--P:regulation of establishment or maintenance of cell polarity
GO:0050708--P:regulation of protein secretion
GO:0035070--P:salivary gland histolysis
GO:0007423--P:sensory organ development
GO:0019991--P:septate junction assembly
GO:0098725--P:symmetric cell division
GO:0016082--P:synaptic vesicle priming
GO:0007179--P:transforming growth factor beta receptor signaling pathway