| Tag |
Content |
| dbPAF ID |
dbPAF-0004625 |
| Uniprot Accession |
P07713; DECA_DROME; A4V009; P91651; Q6AWM1; Q8I0M7; Q8ITK4; Q9VQC6;
|
| Genbank Protein ID |
NP_477311.1; NP_722810.1; NP_722811.1; NP_722813.1;
|
| Genbank Nucleotide ID |
NM_057963.5; NM_164485.2; NM_164486.2; NM_164488.2;
|
| Protein Name |
Protein decapentaplegic |
| Protein Synonyms/Alias |
|
| Gene Name |
dpp |
| Gene Synonyms/Alias |
CG9885; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.Functional Description
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MRAWLLLLAV LATFQTIVRV ASTEDISQRF IAAIAPVAAH IPLASASGSG SGRSGSRSVG 60
ASTSTALAKA FNPFSEPASF SDSDKSHRSK TNKKPSKSDA NRQFNEVHKP RTDQLENSKN 120
KSKQLVNKPN HNKMAVKEQR SHHKKSHHHR SHQPKQASAS TESHQSSSIE SIFVEEPTLV 180
LDREVASINV PANAKAIIAE QGPSTYSKEA LIKDKLKPDP STLVEIEKSL LSLFNMKRPP 240
KIDRSKIIIP EPMKKLYAEI MGHELDSVNI PKPGLLTKSA NTVRSFTHKD SKIDDRFPHH 300
HRFRLHFDVK SIPADEKLKA AELQLTRDAL SQQVVASRSS ANRTRYQVLV YDITRVGVRG 360
QREPSYLLLD TKTVRLNSTD TVSLDVQPAV DRWLASPQRN YGLLVEVRTV RSLKPAPHHH 420
VRLRRSADEA HERWQHKQPL LFTYTDDGRH KARSIRDVSG GEGGGKGGRN KRQPRRPTRR 480
KNHDDTCRRH SLYVDFSDVG WDDWIVAPLG YDAYYCHGKC PFPLADHFNS TNHAVVQTLV 540
NNMNPGKVPK ACCVPTQLDS VAMLYLNDQS TVVLKNYQEM TVVGCGCR
589Fasta Sequence
>P07713|dpp|Drosophila melanogaster(Fruit fly)
MRAWLLLLAVLATFQTIVRVASTEDISQRFIAAIAPVAAHIPLASASGSGSGRSGSRSVGASTSTALAKAFNPFSEPASFSDSDKSHRSKTNKKPSKSDANRQFNEVHKPRTDQLENSKNKSKQLVNKPNHNKMAVKEQRSHHKKSHHHRSHQPKQASASTESHQSSSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFSDVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR029034--Cystine-knot_cytokine
IPR002405--Inhibin_asu
IPR001839--TGF-b_C
IPR001111--TGF-b_N
IPR015615--TGF-beta-rel
IPR017948--TGFb_CS
|
| PROSITE |
PS00250--TGF_BETA_1
PS51362--TGF_BETA_2
|
| Pfam |
PF00019--TGF_beta
PF00688--TGFb_propeptide
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0005622--C:intracellular
GO:0005518--F:collagen binding
GO:0005125--F:cytokine activity
GO:0008201--F:heparin binding
GO:0016015--F:morphogen activity
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0005160--F:transforming growth factor beta receptor binding
GO:0007378--P:amnioserosa formation
GO:0061327--P:anterior Malpighian tubule development
GO:0009948--P:anterior/posterior axis specification
GO:0007448--P:anterior/posterior pattern specification, imaginal disc
GO:0030509--P:BMP signaling pathway
GO:0061353--P:BMP signaling pathway involved in Malpighian tubule cell chemotaxis
GO:0035147--P:branch fusion, open tracheal system
GO:0046845--P:branched duct epithelial cell fate determination, open tracheal system
GO:0010002--P:cardioblast differentiation
GO:0001709--P:cell fate determination
GO:0001708--P:cell fate specification
GO:0007304--P:chorion-containing eggshell formation
GO:0001745--P:compound eye morphogenesis
GO:0048066--P:developmental pigmentation
GO:0046843--P:dorsal appendage formation
GO:0007391--P:dorsal closure
GO:0007393--P:dorsal closure, leading edge cell fate determination
GO:0009950--P:dorsal/ventral axis specification
GO:0007450--P:dorsal/ventral pattern formation, imaginal disc
GO:0007398--P:ectoderm development
GO:0001715--P:ectodermal cell fate specification
GO:0048619--P:embryonic hindgut morphogenesis
GO:0007425--P:epithelial cell fate determination, open tracheal system
GO:0007427--P:epithelial cell migration, open tracheal system
GO:0035214--P:eye-antennal disc development
GO:0007455--P:eye-antennal disc morphogenesis
GO:0036099--P:female germ-line stem cell population maintenance
GO:0007440--P:foregut morphogenesis
GO:0035156--P:fusion cell fate specification
GO:0035224--P:genital disc anterior/posterior pattern formation
GO:0035215--P:genital disc development
GO:0035263--P:genital disc sexually dimorphic development
GO:0007281--P:germ cell development
GO:0008354--P:germ cell migration
GO:0042078--P:germ-line stem cell division
GO:0030718--P:germ-line stem cell population maintenance
GO:0060323--P:head morphogenesis
GO:0007507--P:heart development
GO:0007516--P:hemocyte development
GO:0007442--P:hindgut morphogenesis
GO:0007444--P:imaginal disc development
GO:0007446--P:imaginal disc growth
GO:0007447--P:imaginal disc pattern formation
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0008586--P:imaginal disc-derived wing vein morphogenesis
GO:0007474--P:imaginal disc-derived wing vein specification
GO:0035217--P:labial disc development
GO:0035168--P:larval lymph gland hemocyte differentiation
GO:0007479--P:leg disc proximal/distal pattern formation
GO:0048542--P:lymph gland development
GO:0007443--P:Malpighian tubule morphogenesis
GO:0007313--P:maternal specification of dorsal/ventral axis, oocyte, soma encoded
GO:0007498--P:mesoderm development
GO:0008285--P:negative regulation of cell proliferation
GO:0010629--P:negative regulation of gene expression
GO:0045705--P:negative regulation of salivary gland boundary specification
GO:0045476--P:nurse cell apoptotic process
GO:0048477--P:oogenesis
GO:0007424--P:open tracheal system development
GO:0030707--P:ovarian follicle cell development
GO:0061320--P:pericardial nephrocyte differentiation
GO:0048636--P:positive regulation of muscle organ development
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0007458--P:progression of morphogenetic furrow involved in compound eye morphogenesis
GO:0042981--P:regulation of apoptotic process
GO:0045595--P:regulation of cell differentiation
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045570--P:regulation of imaginal disc growth
GO:0043408--P:regulation of MAPK cascade
GO:0046620--P:regulation of organ growth
GO:0035158--P:regulation of tube diameter, open tracheal system
GO:0007423--P:sensory organ development
GO:0060395--P:SMAD protein signal transduction
GO:0030721--P:spectrosome organization
GO:0017145--P:stem cell division
GO:0019827--P:stem cell population maintenance
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0035309--P:wing and notum subfield formation
GO:0048100--P:wing disc anterior/posterior pattern formation
GO:0035222--P:wing disc pattern formation
GO:0007473--P:wing disc proximal/distal pattern formation
GO:0007354--P:zygotic determination of anterior/posterior axis, embryo
GO:0007352--P:zygotic specification of dorsal/ventral axis
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