dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0004623 |
| Uniprot Accession | P07703; RPAC1_YEAST; D6W4A9; |
| Genbank Protein ID | NP_015435.1; |
| Genbank Nucleotide ID | NM_001184207.1; |
| Protein Name | DNA-directed RNA polymerases I and III subunit RPAC1 |
| Protein Synonyms/Alias | |
| Gene Name | RPC40 |
| Gene Synonyms/Alias | RPC5;YPR110C;P8283.18; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MSNIVGIEYN RVTNTTSTDF PGFSKDAENE WNVEKFKKDF EVNISSLDAR EANFDLINID 60 TSIANAFRRI MISEVPSVAA EYVYFFNNTS VIQDEVLAHR IGLVPLKVDP DMLTWVDSNL 120 PDDEKFTDEN TIVLSLNVKC TRNPDAPKGS TDPKELYNNA HVYARDLKFE PQGRQSTTFA 180 DCPVVPADPD ILLAKLRPGQ EISLKAHCIL GIGGDHAKFS PVSTASYRLL PQINILQPIK 240 GESARRFQKC FPPGVIGIDE GSDEAYVKDA RKDTVSREVL RYEEFADKVK LGRVRNHFIF 300 NVESAGAMTP EEIFFKSVRI LKNKAEYLKN CPITQ 336 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR001514--DNA-dir_RNA_pol_30-40kDasu_CS |
| PROSITE | PS00446--RNA_POL_D_30KD |
| Pfam | |
| Gene Ontology | GO:0005736--C:DNA-directed RNA polymerase I complex |