dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004622
Uniprot Accession P07702; LYS2_YEAST; D6VQB4;
Genbank Protein ID NP_009673.1;
Genbank Nucleotide ID NM_001178463.1;
Protein Name L-2-aminoadipate reductase
Protein Synonyms/Alias Alpha-aminoadipate reductase;Alpha-AR;L-aminoadipate-semialdehyde dehydrogenase;
Gene Name LYS2
Gene Synonyms/Alias YBR115C;YBR0910;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
213SNCITKISLITASSKPhosphoGRID 2.021126336
216ITKISLITASSKDSLPhosphoGRID 2.021126336
880FFDLGGHSILATKMIcurated22817900
926IKSSGGSSQGEVVENdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22817900; 19547744
Sequence
(Fasta)		MTNEKVWIEK LDNPTLSVLP HDFLRPQQEP YTKQATYSLQ LPQLDVPHDS FSNKYAVALS 60
VWAALIYRVT GDDDIVLYIA NNKILRFNIQ PTWSFNELYS TINNELNKLN SIEANFSFDE 120
LAEKIQSCQD LERTPQLFRL AFLENQDFKL DEFKHHLVDF ALNLDTSNNA HVLNLIYNSL 180
LYSNERVTIV ADQFTQYLTA ALSDPSNCIT KISLITASSK DSLPDPTKNL GWCDFVGCIH 240
DIFQDNAEAF PERTCVVETP TLNSDKSRSF TYRDINRTSN IVAHYLIKTG IKRGDVVMIY 300
SSRGVDLMVC VMGVLKAGAT FSVIDPAYPP ARQTIYLGVA KPRGLIVIRA AGQLDQLVED 360
YINDELEIVS RINSIAIQEN GTIEGGKLDN GEDVLAPYDH YKDTRTGVVV GPDSNPTLSF 420
TSGSEGIPKG VLGRHFSLAY YFNWMSKRFN LTENDKFTML SGIAHDPIQR DMFTPLFLGA 480
QLYVPTQDDI GTPGRLAEWM SKYGCTVTHL TPAMGQLLTA QATTPFPKLH HAFFVGDILT 540
KRDCLRLQTL AENCRIVNMY GTTETQRAVS YFEVKSKNDD PNFLKKLKDV MPAGKGMLNV 600
QLLVVNRNDR TQICGIGEIG EIYVRAGGLA EGYRGLPELN KEKFVNNWFV EKDHWNYLDK 660
DNGEPWRQFW LGPRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTHISQ 720
HPLVRENITL VRKNADNEPT LITFMVPRFD KPDDLSKFQS DVPKEVETDP IVKGLIGYHL 780
LSKDIRTFLK KRLASYAMPS LIVVMDKLPL NPNGKVDKPK LQFPTPKQLN LVAENTVSET 840
DDSQFTNVER EVRDLWLSIL PTKPASVSPD DSFFDLGGHS ILATKMIFTL KKKLQVDLPL 900
GTIFKYPTIK AFAAEIDRIK SSGGSSQGEV VENVTANYAE DAKKLVETLP SSYPSREYFV 960
EPNSAEGKTT INVFVTGVTG FLGSYILADL LGRSPKNYSF KVFAHVRAKD EEAAFARLQK 1020
AGITYGTWNE KFASNIKVVL GDLSKSQFGL SDEKWMDLAN TVDIIIHNGA LVHWVYPYAK 1080
LRDPNVISTI NVMSLAAVGK PKFFDFVSST STLDTEYYFN LSDKLVSEGK PGILESDDLM 1140
NSASGLTGGY GQSKWAAEYI IRRAGERGLR GCIVRPGYVT GASANGSSNT DDFLLRFLKG 1200
SVQLGKIPDI ENSVNMVPVD HVARVVVATS LNPPKENELA VAQVTGHPRI LFKDYLYTLH 1260
DYGYDVEIES YSKWKKSLEA SVIDRNEENA LYPLLHMVLD NLPESTKAPE LDDRNAVASL 1320
KKDTAWTGVD WSNGIGVTPE EVGIYIAFLN KVGFLPPPTH NDKLPLPSIE LTQAQISLVA 1380
SGAGARGSSA AA 1393
Keyword

KW-0028--Amino-acid biosynthesis
KW-0181--Complete proteome
KW-0457--Lysine biosynthesis
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0596--Phosphopantetheine
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR010071--AA_adenyl_domain
IPR009081--Acyl_carrier_prot-like
IPR025110--AMP-bd_C
IPR020845--AMP-binding_CS
IPR000873--AMP-dep_Synth/Lig
IPR014397--Lys2
IPR013120--Male_sterile_NAD-bd
IPR016040--NAD(P)-bd_dom
IPR006162--Ppantetheine_attach_site
IPR010080--Thioester_reductase-like_dom
PROSITE

PS50075--ACP_DOMAIN
PS00455--AMP_BINDING
PS00012--PHOSPHOPANTETHEINE
Pfam

PF00501--AMP-binding
PF13193--AMP-binding_C
PF07993--NAD_binding_4
PF00550--PP-binding
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004043--F:L-aminoadipate-semialdehyde dehydrogenase activity
GO:0019878--P:lysine biosynthetic process via aminoadipic acid