| Tag |
Content |
| dbPAF ID |
dbPAF-0004616 |
| Uniprot Accession |
P07663; PER_DROME; O17483; O76882; O76883; O76884; O76885; Q24446; Q24447; Q24448; Q24449; Q6PVA3; Q8MLY0; Q9GN20; Q9GN51; Q9GQH9; Q9GV48; Q9GV53; Q9GV54; Q9GV55; Q9W4X0;
|
| Genbank Protein ID |
NP_001259194.1; NP_525056.2;
|
| Genbank Nucleotide ID |
NM_001272265.1; NM_080317.2;
|
| Protein Name |
Period circadian protein |
| Protein Synonyms/Alias |
Protein clock-6;CLK-6; |
| Gene Name |
per |
| Gene Synonyms/Alias |
CG2647; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.Functional Description
Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 60
SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 120
ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 180
VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 240
CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 300
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 360
GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 420
GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 480
PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 540
PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 600
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 660
SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 720
GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 780
EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 840
TLGTDAIKGA AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 900
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH STHTAMAQSS 960
FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP TTSQQAAAAA AQAMPLQYMA 1020
GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP GMANALQIPE RPLGSQSAYN KSVYTTTPAS 1080
MTKKVPGAFH SVTTPAQVQR PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN 1140
SDPPCSSSNP ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 1200
KSMSTSESKI MEHPEEDQTQ HGDG
1225Fasta Sequence
>P07663|per|Drosophila melanogaster(Fruit fly)
MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGTASSSKGGTAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEHPEEDQTQHGDG
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
|
| Interpro |
IPR001610--PAC
IPR000014--PAS
IPR013767--PAS_fold
|
| PROSITE |
PS50112--PAS
|
| Pfam |
PF00989--PAS
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0003712--F:transcription cofactor activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0001306--P:age-dependent response to oxidative stress
GO:0048148--P:behavioral response to cocaine
GO:0048512--P:circadian behavior
GO:0007623--P:circadian rhythm
GO:0042745--P:circadian sleep/wake cycle
GO:0060086--P:circadian temperature homeostasis
GO:0007620--P:copulation
GO:0007619--P:courtship behavior
GO:0008340--P:determination of adult lifespan
GO:0008062--P:eclosion rhythm
GO:0009649--P:entrainment of circadian clock
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0007616--P:long-term memory
GO:0045433--P:male courtship behavior, veined wing generated song production
GO:0007617--P:mating behavior
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:2000678--P:negative regulation of transcription regulatory region DNA binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042752--P:regulation of circadian rhythm
GO:0045187--P:regulation of circadian sleep/wake cycle, sleep
GO:1904059--P:regulation of locomotor rhythm
GO:0001932--P:regulation of protein phosphorylation
GO:0009416--P:response to light stimulus
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus
GO:0007622--P:rhythmic behavior
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