dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004610
Uniprot Accession P07560; SEC4_YEAST; D6VTM4;
Genbank Protein ID NP_116650.1;
Genbank Nucleotide ID NM_001179961.1;
Protein Name Ras-related protein SEC4
Protein Synonyms/Alias Suppressor of RHO3 protein 6;
Gene Name SEC4
Gene Synonyms/Alias SRO6;YFL005W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
2------MSGLRTVSAPhosphoGRID 2.0;curated19823750; 19795423
6--MSGLRTVSASSGNPhosphoGRID 2.0;curated19779198; 19823750
8MSGLRTVSASSGNGKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated11875433; 16381945; 23193290; 21177495; 19823750; 19795423;
10GLRTVSASSGNGKSYcurated19823750
11LRTVSASSGNGKSYDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated11875433; 16381945; 23193290; 21177495; 19823750; 19795423;
16ASSGNGKSYDSIMKIPhosphoGRID 2.0;curated21177495; 22817900
201NGKEGNISINSGSGNdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated11875433; 17330950; 18407956; 16381945; 23193290; 21126336;
204EGNISINSGSGNSSKdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated11875433; 17330950; 18407956; 16381945; 23193290; 20702584;
206NISINSGSGNSSKSNPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 24603354; 22817900; 25521595; 25315811
209INSGSGNSSKSNCC-curated25315811
210NSGSGNSSKSNCC--curated25521595
Sequence
(Fasta)		MSGLRTVSAS SGNGKSYDSI MKILLIGDSG VGKSCLLVRF VEDKFNPSFI TTIGIDFKIK 60
TVDINGKKVK LQLWDTAGQE RFRTITTAYY RGAMGIILVY DVTDERTFTN IKQWFKTVNE 120
HANDEAQLLL VGNKSDMETR VVTADQGEAL AKELGIPFIE SSAKNDDNVN EIFFTLAKLI 180
QEKIDSNKLV GVGNGKEGNI SINSGSGNSS KSNCC 216
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0268--Exocytosis
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0636--Prenylation
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR003579--Small_GTPase_Rab_type
PROSITE

PS51419--RAB
Pfam

PF00071--Ras
Gene Ontology

GO:0005768--C:endosome
GO:0000131--C:incipient cellular bud site
GO:0043332--C:mating projection tip
GO:0005886--C:plasma membrane
GO:0030667--C:secretory granule membrane
GO:0030133--C:transport vesicle
GO:0030658--C:transport vesicle membrane
GO:0031982--C:vesicle
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0031321--P:ascospore-type prospore assembly
GO:0006914--P:autophagy
GO:0006887--P:exocytosis
GO:0006893--P:Golgi to plasma membrane transport
GO:0006886--P:intracellular protein transport
GO:0007107--P:membrane addition at site of cytokinesis
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0032482--P:Rab protein signal transduction
GO:0017157--P:regulation of exocytosis
GO:0006904--P:vesicle docking involved in exocytosis
GO:0006906--P:vesicle fusion