dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0004562
Uniprot Accession P07277; KIME_YEAST; D6W033;
Genbank Protein ID NP_013935.1;
Genbank Nucleotide ID NM_001182715.1;
Protein Name Mevalonate kinase
Protein Synonyms/Alias
Gene Name ERG12
Gene Synonyms/Alias RAR1;YMR208W;YM8261.02;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
May contribute to the regulation of the isoprenoid and sterol pathway in living cells.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
64ISFNHKWSINDFNAIPhosphoGRID 2.020489023
Sequence
(Fasta)
MSLPFLTSAP GKVIIFGEHS AVYNKPAVAA SVSALRTYLL ISESSAPDTI ELDFPDISFN 60
HKWSINDFNA ITEDQVNSQK LAKAQQATDG LSQELVSLLD PLLAQLSESF HYHAAFCFLY 120
MFVCLCPHAK NIKFSLKSTL PIGAGLGSSA SISVSLALAM AYLGGLIGSN DLEKLSENDK 180
HIVNQWAFIG EKCIHGTPSG IDNAVATYGN ALLFEKDSHN GTINTNNFKF LDDFPAIPMI 240
LTYTRIPRST KDLVARVRVL VTEKFPEVMK PILDAMGECA LQGLEIMTKL SKCKGTDDEA 300
VETNNELYEQ LLELIRINHG LLVSIGVSHP GLELIKNLSD DLRIGSTKLT GAGGGGCSLT 360
LLRRDITQEQ IDSFKKKLQD DFSYETFETD LGGTGCCLLS AKNLNKDLKI KSLVFQLFEN 420
KTTTKQQIDD LLLPGNTNLP WTS 444
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0808--Transferase

Interpro

IPR013750--GHMP_kinase_C_dom
IPR006204--GHMP_kinase_N_dom
IPR006203--GHMP_knse_ATP-bd_CS
IPR006205--Mev_gal_kin
IPR006206--Mevalonate/galactokinase
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr

PROSITE

PS00627--GHMP_KINASES_ATP

Pfam

PF00288--GHMP_kinases_N

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004496--F:mevalonate kinase activity
GO:0006696--P:ergosterol biosynthetic process
GO:0010142--P:farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287--P:isopentenyl diphosphate biosynthetic process, mevalonate pathway