Tag |
Content |
dbPAF ID |
dbPAF-0004562 |
Uniprot Accession |
P07277; KIME_YEAST; D6W033; |
Genbank Protein ID |
NP_013935.1; |
Genbank Nucleotide ID |
NM_001182715.1; |
Protein Name |
Mevalonate kinase |
Protein Synonyms/Alias |
|
Gene Name |
ERG12 |
Gene Synonyms/Alias |
RAR1;YMR208W;YM8261.02; |
Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
NCBI Taxa ID |
559292 |
Functional Description (View all) |
May contribute to the regulation of the isoprenoid and sterol pathway in living cells.Functional Description
May contribute to the regulation of the isoprenoid and sterol pathway in living cells.
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
---|
64 | ISFNHKWSINDFNAI | PhosphoGRID 2.0 | 20489023 |
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Sequence (Fasta) | MSLPFLTSAP GKVIIFGEHS AVYNKPAVAA SVSALRTYLL ISESSAPDTI ELDFPDISFN 60 HKWSINDFNA ITEDQVNSQK LAKAQQATDG LSQELVSLLD PLLAQLSESF HYHAAFCFLY 120 MFVCLCPHAK NIKFSLKSTL PIGAGLGSSA SISVSLALAM AYLGGLIGSN DLEKLSENDK 180 HIVNQWAFIG EKCIHGTPSG IDNAVATYGN ALLFEKDSHN GTINTNNFKF LDDFPAIPMI 240 LTYTRIPRST KDLVARVRVL VTEKFPEVMK PILDAMGECA LQGLEIMTKL SKCKGTDDEA 300 VETNNELYEQ LLELIRINHG LLVSIGVSHP GLELIKNLSD DLRIGSTKLT GAGGGGCSLT 360 LLRRDITQEQ IDSFKKKLQD DFSYETFETD LGGTGCCLLS AKNLNKDLKI KSLVFQLFEN 420 KTTTKQQIDD LLLPGNTNLP WTS
444Fasta Sequence
>P07277|ERG12|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS
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Keyword |
KW-0067--ATP-binding KW-0181--Complete proteome KW-0963--Cytoplasm KW-0418--Kinase KW-0444--Lipid biosynthesis KW-0443--Lipid metabolism KW-0547--Nucleotide-binding KW-1185--Reference proteome KW-0752--Steroid biosynthesis KW-0753--Steroid metabolism KW-0756--Sterol biosynthesis KW-1207--Sterol metabolism KW-0808--Transferase
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Interpro |
IPR013750--GHMP_kinase_C_dom IPR006204--GHMP_kinase_N_dom IPR006203--GHMP_knse_ATP-bd_CS IPR006205--Mev_gal_kin IPR006206--Mevalonate/galactokinase IPR020568--Ribosomal_S5_D2-typ_fold IPR014721--Ribosomal_S5_D2-typ_fold_subgr
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PROSITE |
PS00627--GHMP_KINASES_ATP
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Pfam |
PF00288--GHMP_kinases_N
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005524--F:ATP binding GO:0004496--F:mevalonate kinase activity GO:0006696--P:ergosterol biosynthetic process GO:0010142--P:farnesyl diphosphate biosynthetic process, mevalonate pathway GO:0019287--P:isopentenyl diphosphate biosynthetic process, mevalonate pathway
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