dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004561
Uniprot Accession P07276; RAD2_YEAST; D6VV38; E9P8X9;
Genbank Protein ID NP_011774.1;
Genbank Nucleotide ID NM_001181387.1;
Protein Name DNA repair protein RAD2
Protein Synonyms/Alias
Gene Name RAD2
Gene Synonyms/Alias YGR258C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
118ALQLQNGSNDNVKNSPhosphoGRID 2.0;UniProt;curated20489023; 19779198; 22369663; 22817900; 24961812; 25315811;
321ALVKQLDSNAEDGDVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
346LKIVRHESSNATTAPPhosphoGRID 2.020489023
347KIVRHESSNATTAPQcurated25315811
360PQKRSNRSEDEGCDScurated26040289
367SEDEGCDSDECEWEEPhosphoGRID 2.0;UniProt;curated19779198; 26040289; 25315811
419DKRHDQASPSKTTPTPhosphoPep 2.0;curated19060867; 26040406
502QPDSKQPYHVTNLNScurated22817900
509YHVTNLNSKSESVIKcurated22817900
530LSEFRPPSQQEDKGAcurated24961812
575KNTESNVSQEATKEKPhosphoGRID 2.0;curated20489023; 25315811
583QEATKEKSPIPEMPSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 24961812
621NVRNEQESGAETTNKPhosphoGRID 2.020489023
666DDDLEVLSEELFEDVcurated24961812
709LIFDYDFSEDEEDNIcurated24961812
Sequence
(Fasta)		MGVHSFWDIA GPTARPVRLE SLEDKRMAVD ASIWIYQFLK AVRDQEGNAV KNSHITGFFR 60
RICKLLYFGI RPVFVFDGGV PVLKRETIRQ RKERRQGKRE SAKSTARKLL ALQLQNGSND 120
NVKNSTPSSG SSVQIFKPQD EWDLPDIPGF KYDKEDARVN SNKTFEKLMN SINGDGLEDI 180
DLDTINPASA EFEELPKATQ YLILSSLRLK SRLRMGYSKE QLETIFPNSM DFSRFQIDMV 240
KRRNFFTQKL INTTGFQDGG ASKLNEEVIN RISGQKSKEY KLTKTNNGWI LGLGANDGSD 300
AQKAIVIDDK DAGALVKQLD SNAEDGDVLR WDDLEDNSLK IVRHESSNAT TAPQKRSNRS 360
EDEGCDSDEC EWEEVELKPK NVKFVEDFSL KAARLPYMGQ SLNNAGSKSF LDKRHDQASP 420
SKTTPTMRIS RISVEDDDED YLKQIEEIEM MEAVQLSKME KKPEADDKSK IAKPVTSKGT 480
EARPPIVQYG LLGAQPDSKQ PYHVTNLNSK SESVIKRTSK TVLSEFRPPS QQEDKGAILT 540
EGEQNLNFIS HKIPQFDFNN ENSLLFQKNT ESNVSQEATK EKSPIPEMPS WFSSTASQQL 600
YNPYNTTNFV EDKNVRNEQE SGAETTNKGS SYELLTGLNA TEILERESEK ESSNDENKDD 660
DLEVLSEELF EDVPTKSQIS KEAEDNDSRK VESINKEHRK PLIFDYDFSE DEEDNIVENM 720
IKEQEEFDTF KNTTLSTSAE RNVAENAFVE DELFEQQMKD KRDSDEVTMD MIKEVQELLS 780
RFGIPYITAP MEAEAQCAEL LQLNLVDGII TDDSDVFLFG GTKIYKNMFH EKNYVEFYDA 840
ESILKLLGLD RKNMIELAQL LGSDYTNGLK GMGPVSSIEV IAEFGNLKNF KDWYNNGQFD 900
KRKQETENKF EKDLRKKLVN NEIILDDDFP SVMVYDAYMR PEVDHDTTPF VWGVPDLDML 960
RSFMKTQLGW PHEKSDEILI PLIRDVNKRK KKGKQKRINE FFPREYISGD KKLNTSKRIS 1020
TATGKLKKRK M 1032
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR020045--5-3_exonuclease_C
IPR008918--HhH2
IPR029060--PIN_domain-like
IPR006086--XPG-I_dom
IPR006084--XPG/Rad2
IPR001044--XPG/Rad2_eukaryotes
IPR019974--XPG_CS
IPR006085--XPG_DNA_repair_N
PROSITE

PS00841--XPG_1
PS00842--XPG_2
Pfam

PF00867--XPG_I
PF00752--XPG_N
Gene Ontology

GO:0000112--C:nucleotide-excision repair factor 3 complex
GO:0046872--F:metal ion binding
GO:0003697--F:single-stranded DNA binding
GO:0000014--F:single-stranded DNA endodeoxyribonuclease activity
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006366--P:transcription from RNA polymerase II promoter