dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004560
Uniprot Accession P07274; PROF_YEAST; D6W2I0;
Genbank Protein ID NP_014765.3;
Genbank Nucleotide ID NM_001183541.3;
Protein Name Profilin
Protein Synonyms/Alias
Gene Name PFY1
Gene Synonyms/Alias PFY;PRF1;YOR122C;O3275;YOR3275C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
2------MSWQAYTDNPhosphoGRID 2.0;PHOSIDA;curated21126336; 21081558; 26040289; 22369663; 19795423; 24961812
Sequence
(Fasta)		MSWQAYTDNL IGTGKVDKAV IYSRAGDAVW ATSGGLSLQP NEIGEIVQGF DNPAGLQSNG 60
LHIQGQKFML LRADDRSIYG RHDAEGVVCV RTKQTVIIAH YPPTVQAGEA TKIVEQLADY 120
LIGVQY 127
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
Interpro

IPR005455--PFN
IPR027310--Profilin_CS
PROSITE

PS00414--PROFILIN
Pfam

PF00235--Profilin
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0019897--C:extrinsic component of plasma membrane
GO:0003785--F:actin monomer binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0070064--F:proline-rich region binding
GO:0046907--P:intracellular transport
GO:0090338--P:positive regulation of formin-nucleated actin cable assembly
GO:0042989--P:sequestering of actin monomers