| Tag |
Content |
| dbPAF ID |
dbPAF-0004559 |
| Uniprot Accession |
P07273; TFS2_YEAST; D6VU96; P24535;
|
| Genbank Protein ID |
NP_011472.1;
|
| Genbank Nucleotide ID |
NM_001180908.1;
|
| Protein Name |
Transcription elongation factor S-II |
| Protein Synonyms/Alias |
DNA strand transfer protein alpha;STP-alpha;DNA strand transferase 1;Pyrimidine pathway regulatory protein 2; |
| Gene Name |
DST1 |
| Gene Synonyms/Alias |
PPR2;YGL043W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.Functional Description
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MDSKEVLVHV KNLEKNKSND AAVLEILHVL DKEFVPTEKL LRETKVGVEV NKFKKSTNVE 60
ISKLVKKMIS SWKDAINKNK RSRQAQQHHQ DHAPGNAEDK TTVGESVNGV QQPASSQSDA 120
MKQDKYVSTK PRNSKNDGVD TAIYHHKLRD QVLKALYDVL AKESEHPPQS ILHTAKAIES 180
EMNKVNNCDT NEAAYKARYR IIYSNVISKN NPDLKHKIAN GDITPEFLAT CDAKDLAPAP 240
LKQKIEEIAK QNLYNAQGAT IERSVTDRFT CGKCKEKKVS YYQLQTRSAD EPLTTFCTCE 300
ACGNRWKFS
Fasta Sequence
>P07273|DST1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MDSKEVLVHVKNLEKNKSNDAAVLEILHVLDKEFVPTEKLLRETKVGVEVNKFKKSTNVEISKLVKKMISSWKDAINKNKRSRQAQQHHQDHAPGNAEDKTTVGESVNGVQQPASSQSDAMKQDKYVSTKPRNSKNDGVDTAIYHHKLRDQVLKALYDVLAKESEHPPQSILHTAKAIESEMNKVNNCDTNEAAYKARYRIIYSNVISKNNPDLKHKIANGDITPEFLATCDAKDLAPAPLKQKIEEIAKQNLYNAQGATIERSVTDRFTCGKCKEKKVSYYQLQTRSADEPLTTFCTCEACGNRWKFS
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR016492--TF_IIS-rel
IPR003617--TFIIS/CRSP70_N_sub
IPR003618--TFIIS_cen_dom
IPR017923--TFIIS_N
IPR017890--TFS2M
IPR006289--TFSII
IPR001222--Znf_TFIIS
|
| PROSITE |
PS51321--TFIIS_CENTRAL
PS51319--TFIIS_N
PS00466--ZF_TFIIS_1
PS51133--ZF_TFIIS_2
|
| Pfam |
PF08711--Med26
PF01096--TFIIS_C
PF07500--TFIIS_M
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0000993--F:RNA polymerase II core binding
GO:0001012--F:RNA polymerase II regulatory region DNA binding
GO:0001139--F:transcription factor activity, core RNA polymerase II recruiting
GO:0008270--F:zinc ion binding
GO:0001193--P:maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
GO:0045899--P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0031440--P:regulation of mRNA 3'-end processing
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0031564--P:transcription antitermination
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006383--P:transcription from RNA polymerase III promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0042797--P:tRNA transcription from RNA polymerase III promoter
|
