dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004556
Uniprot Accession P07270; PHO4_YEAST; D6VTR7;
Genbank Protein ID NP_116692.1;
Genbank Nucleotide ID NM_001179999.1;
Protein Name Phosphate system positive regulatory protein PHO4
Protein Synonyms/Alias
Gene Name PHO4
Gene Synonyms/Alias YFR034C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MGRTTSEGIHGPhosphoGRID 2.0;curated16825185; 19823750
5---MGRTTSEGIHGFPhosphoGRID 2.016825185
6--MGRTTSEGIHGFVPhosphoGRID 2.0;curated16825185; 26040289; 19823750
100MPSHAHHSPATTATIdbPTM 3.0;PhosphoGRID 2.08539622; 10320381; 16381945; 23193290; 11237614; 16825185
113TIKPRLLYSPLIHTQcurated20377248
114IKPRLLYSPLIHTQSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;curated8539622; 10320381; 16381945; 23193290; 11237614; 16825185; 1
121SPLIHTQSAVPVTIScurated20377248
126TQSAVPVTISPNLVAcurated24961812
128SAVPVTISPNLVATAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated8539622; 10320381; 18407956; 16381945; 23193290; 19779198; 1
149NKVTKNKSNSSPYLNcurated26040289
151VTKNKSNSSPYLNKRPhosphoGRID 2.0;curated16825185; 22369663; 19823750
152TKNKSNSSPYLNKRRdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated8539622; 10320381; 18407956; 16381945; 23193290; 21177495; 1
154NKSNSSPYLNKRRGKPhosphoGRID 2.0;PhosphoPep 2.0;curated19823750; 19795423; 19060867; 22817900
166RGKPGPDSATSLFELPhosphoGRID 2.016825185
168KPGPDSATSLFELPDcurated24961812
169PGPDSATSLFELPDScurated24961812
197YPKVILPSNSTRRVScurated19823750
204SNSTRRVSPVTAKTSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19060867; 19366988;
223GVVVASESPVIAPHGdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated8539622; 10320381; 17330950; 16381945; 23193290; 14624238; 1
238SSHSRSLSKRRSSGAcurated20377248
Sequence
(Fasta)		MGRTTSEGIH GFVDDLEPKS SILDKVGDFI TVNTKRHDGR EDFNEQNDEL NSQENHNSSE 60
NGNENENEQD SLALDDLDRA FELVEGMDMD WMMPSHAHHS PATTATIKPR LLYSPLIHTQ 120
SAVPVTISPN LVATATSTTS ANKVTKNKSN SSPYLNKRRG KPGPDSATSL FELPDSVIPT 180
PKPKPKPKQY PKVILPSNST RRVSPVTAKT SSSAEGVVVA SESPVIAPHG SSHSRSLSKR 240
RSSGALVDDD KRESHKHAEQ ARRNRLAVAL HELASLIPAE WKQQNVSAAP SKATTVEAAC 300
RYIRHLQQNV ST 313
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011598--bHLH_dom
PROSITE

PS50888--BHLH
Pfam

PF00010--HLH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0016036--P:cellular response to phosphate starvation
GO:0006338--P:chromatin remodeling
GO:0045937--P:positive regulation of phosphate metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated