dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004555
Uniprot Accession P07269; PHO2_YEAST; D6VRP4;
Genbank Protein ID NP_010177.1;
Genbank Nucleotide ID NM_001180165.1;
Protein Name Regulatory protein PHO2
Protein Synonyms/Alias General regulatory factor 10;
Gene Name PHO2
Gene Synonyms/Alias BAS2;GRF10;YDL106C;D2350;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
146SNKDTIPSSQSRDIAdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
170NNLVTTTSTSSIFHDcurated22817900
194PLNSNNNYYFFDICScurated26040406
195LNSNNNYYFFDICSIcurated26040406
201YYFFDICSITVGSWNcurated26040406
230IKELRNLSPIKINNIPhosphoGRID 2.012232617; 10884387
306SDKNNSNTNNDDDNDcurated25315811
316DDDNDDNSNEDNDNSPhosphoPep 2.0;curated19060867; 26040406; 25315811; 22817900
323SNEDNDNSSEDKRNAcurated25315811
324NEDNDNSSEDKRNAKcurated25315811
542TDSELPNTPDFLKNTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MMEEFSYDHD FNTHFATDLD YLQHDQQQQQ QQQHDQQHNQ QQQPQPQPIQ TQNLEHDHDQ 60
HTNDMSASSN ASDSGPQRPK RTRAKGEALD VLKRKFEINP TPSLVERKKI SDLIGMPEKN 120
VRIWFQNRRA KLRKKQHGSN KDTIPSSQSR DIANDYDRGS TDNNLVTTTS TSSIFHDEDL 180
TFFDRIPLNS NNNYYFFDIC SITVGSWNRM KSGALQRRNF QSIKELRNLS PIKINNIMSN 240
ATDLMVLISK KNSEINYFFS AMANNTKILF RIFFPLSSVT NCSLTLETDD DIINSNNTSD 300
KNNSNTNNDD DNDDNSNEDN DNSSEDKRNA KDNFGELKLT VTRSPTFAVY FLNNAPDEDP 360
NLNNQWSICD DFSEGRQVND AFVGGSNIPH TLKGLQKSLR FMNSLILDYK SSNEILPTIN 420
TAIPTAAVPQ QNIAPPFLNT NSSATDSNPN TNLEDSLFFD HDLLSSSITN TNNGQGSNNG 480
RQASKDDTLN LLDTTVNSNN NHNANNEENH LAQEHLSNDA DIVANPNDHL LSLPTDSELP 540
NTPDFLKNTN ELTDEHRWI
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
PROSITE

PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
Pfam

PF00046--Homeobox
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0006338--P:chromatin remodeling
GO:0000105--P:histidine biosynthetic process
GO:0043388--P:positive regulation of DNA binding
GO:0045937--P:positive regulation of phosphate metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0009113--P:purine nucleobase biosynthetic process
GO:0006366--P:transcription from RNA polymerase II promoter