dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004553
Uniprot Accession P07263; SYH_YEAST; D6W443; Q12095;
Genbank Protein ID NP_015358.1;
Genbank Nucleotide ID NM_001184130.1;
Protein Name Histidine--tRNA ligase, mitochondrial
Protein Synonyms/Alias Histidyl-tRNA synthetase;HisRS;
Gene Name HTS1
Gene Synonyms/Alias YPR033C;YP9367.13C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
3-----MLSRSLNKVVcurated19823750
5---MLSRSLNKVVTScurated19823750
17VTSIKSSSIIRMSSAcurated22369663
Sequence
(Fasta)		MLSRSLNKVV TSIKSSSIIR MSSATAAATS APTANAANAL KASKAPKKGK LQVSLKTPKG 60
TKDWADSDMV IREAIFSTLS GLFKKHGGVT IDTPVFELRE ILAGKYGEDS KLIYNLEDQG 120
GELCSLRYDL TVPFARYVAM NNIQSIKRYH IAKVYRRDQP AMTKGRMREF YQCDFDVAGT 180
FESMVPDSEC LSILVEGLTS LGIKDFKIKL NHRKILDGIF QIAGVKDEDV RKISSAVDKL 240
DKSPWEAVKK EMTEEKGQSE ETADKIGEYV KLNGSLKEIH AVLSADANIT SNEKAKQGLD 300
DIATLMKYTE AFDIDSFISF DLSLARGLDY YTGLIYEVVT SASAPPENAS ELKKKAKSAE 360
DASEFVGVGS IAAGGRYDNL VNMFSEASGK KSTQIPCVGI SFGVERIFSL IKQRINSSTT 420
IKPTATQVFV MAFGGGKDWT GYLPERMKVT KQLWDAGIEA EYVYKAKANP RKQFDAAEKA 480
GCHIAVILGK EEYLEGKLRV KRLGQEFADD DGELVSAADI VPIVQEKLSQ IHEDGLNEVT 540
RLIKGL 547
Keyword

KW-0024--Alternative initiation
KW-0030--Aminoacyl-tRNA synthetase
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR006195--aa-tRNA-synth_II
IPR004154--Anticodon-bd
IPR015807--His-tRNA-ligase
IPR004516--HisRS/HisZ
PROSITE

PS50862--AA_TRNA_LIGASE_II
Pfam

PF03129--HGTP_anticodon
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0004812--F:aminoacyl-tRNA ligase activity
GO:0005524--F:ATP binding
GO:0004821--F:histidine-tRNA ligase activity
GO:0006427--P:histidyl-tRNA aminoacylation
GO:0032543--P:mitochondrial translation