dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0004550
Uniprot Accession P07260; IF4E_YEAST; D6W1T0;
Genbank Protein ID NP_014502.1;
Genbank Nucleotide ID NM_001183393.1;
Protein Name Eukaryotic translation initiation factor 4E
Protein Synonyms/Alias
Gene Name CDC33
Gene Synonyms/Alias TIF45;YOL139C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
2------MSVEEVSKKdbPTM 3.0;Phospho.ELM 9.0;PhosphoGRID 2.0;curated7592868; 16381945; 23193290; 26040406
7-MSVEEVSKKFEENVcurated26040406
15KKFEENVSVDDTTATdbPTM 3.0;Phospho.ELM 9.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated7592868; 15665377; 17287358; 17330950; 17563356; 18407956; 1
19ENVSVDDTTATPKTVcurated24961812; 25521595
20NVSVDDTTATPKTVLcurated26040406; 22817900; 19823750; 25315811
22SVDDTTATPKTVLSDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
25DTTATPKTVLSDSAHcurated25882841
28ATPKTVLSDSAHFDVdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 20702584; 19779198;
30PKTVLSDSAHFDVKHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 20702584;
Sequence
(Fasta)		MSVEEVSKKF EENVSVDDTT ATPKTVLSDS AHFDVKHPLN TKWTLWYTKP AVDKSESWSD 60
LLRPVTSFQT VEEFWAIIQN IPEPHELPLK SDYHVFRNDV RPEWEDEANA KGGKWSFQLR 120
GKGADIDELW LRTLLAVIGE TIDEDDSQIN GVVLSIRKGG NKFALWTKSE DKEPLLRIGG 180
KFKQVLKLTD DGHLEFFPHS SANGRHPQPS ITL 214
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0810--Translation regulation
Interpro

IPR023398--TIF_eIF4e-like
IPR001040--TIF_eIF_4E
IPR019770--TIF_eIF_4E_CS
PROSITE

PS00813--IF4E
Pfam

PF01652--IF4E
Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0016281--C:eukaryotic translation initiation factor 4F complex
GO:0005634--C:nucleus
GO:0005840--C:ribosome
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0003743--F:translation initiation factor activity
GO:0000184--P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0051726--P:regulation of cell cycle
GO:0006417--P:regulation of translation
GO:0006413--P:translational initiation